Designing the new
We design novel proteins using structure-aware AI/optimization models. Our designed proteins find application in energy, environment, therapeutics, and critical ionic separations.
We are located within the Nanovaccine Institute and affiliated to the Chemical & Biological Engineering department at Iowa State.
▲ Engineering rationale for protein pores
In this systematic review, we pinpoint locations on all protein pores reported till date in industry and academia alike which provides a biochemical rationale behind the location and type of mutation, and the specific application of these engineered pores.
▲ AI-guided protein structure prediction
A protein language model using orders of magnitude less computing time than state-of-the-art AlphaFold2 while outperforming them on certain proteins. Enables rapid generation of designed proteins which fold, and screen them for function.
▲ Design protein pores
Protein pores offer naturally-optimized sieves for molecular and ionic separations. We learn how certains amino acid sequences fold into pores with selective interiors. We tune existing pores/ design them from scratch for a wide-range of separations.
