substrate_name: Butanal


enzyme_display_name: aldehyde oxidase

organism: Mus musculus

source_db: brenda

verification_status: unverified

ki_display: Not reported

kcat_over_km_display: Not reported

mutation_signature: Unknown

source_license: CC BY 4.0

km_unit: mM


substrate_name: pentanal


substrate_name: propionaldehyde


substrate_name: benzaldehyde


substrate_name: Phthalazine


substrate_name: octanal


substrate_name: Salicylaldehyde


substrate_name: crotonaldehyde


substrate_name: ethyl vanillin


substrate_name: phenylpropionaldehyde


substrate_name: acetaldehyde


enzyme_display_name: oxalate oxidase

organism: Hordeum vulgare

substrate_name: Oxalate

source_db: oed

protein_accession_database: UniProt


substrate_name: phenanthridine


substrate_name: cinnamaldehyde


substrate_name: phenylacetaldehyde


substrate_name: purine


substrate_name: allopurinol


enzyme_display_name: pyridoxal oxidase

organism: Drosophila melanogaster

substrate_name: pyridoxal

kcat_display: Not reported


organism: Cavia porcellus


substrate_name: Unknown

km_display: Not reported

ki_unit: mM


organism: Macaca fascicularis


organism: Oryctolagus cuniculus

substrate_name: N-methylnicotinamide


substrate_name: hypoxanthine


substrate_name: xanthine


substrate_name: retinalaldehyde


substrate_name: Vanillin


substrate_name: Salicylaldehyde


enzyme_display_name: indole-3-acetaldehyde oxidase

organism: Avena sativa


enzyme_display_name: Abscisic-aldehyde oxidase

organism: Arabidopsis thaliana

substrate_name: abscisic aldehyde

source_db: uniprot


substrate_name: benzaldehyde


enzyme_display_name: pyruvate oxidase

organism: Lactobacillus plantarum


substrate_name: Phosphate

kcat_over_km_origin: calculated


enzyme_display_name: Indole-3-acetaldehyde oxidase

substrate_name: heptaldehyde


substrate_name: protocatechualdehyde


substrate_name: cinnamaldehyde


substrate_name: citral


substrate_name: naphthaldehyde


substrate_name: retinaldehyde


substrate_name: Phthalazine


substrate_name: acetaldehyde


substrate_name: methylene blue


substrate_name: diphenylsulfoxide


substrate_name: ferricyanide


organism: Cupriavidus necator


substrate_name: NAD+


substrate_name: NADP+


enzyme_display_name: cinnamoyl-CoA reductase

substrate_name: caffeoyl-CoA


substrate_name: feruloyl-CoA


substrate_name: sinapoyl-CoA


enzyme_display_name: Aldehyde oxidase 4

substrate_name: benzoic acid (BA) (at pH7, in the presence of NAD(+))


substrate_name: indole-3-acetaldehyde (at pH7)


substrate_name: cinnamylaldehyde (at pH7)


organism: Zea mays

substrate_name: (indol-3-yl)acetaldehyde (at pH 7.4 and 30 degrees Celsius, with O2 as electron acceptor)

verification_status: verified


substrate_name: indol-3-aldehyde (at pH 7.4 and 30 degrees Celsius, with O2 as electron acceptor)


substrate_name: benzaldehyde (at pH 7.4 and 30 degrees Celsius, with O2 as electron acceptor)


substrate_name: protocatechualdehyde (at pH 7.4 and 30 degrees Celsius, with O2 as electron acceptor)


substrate_name: phenylacetaldehyde (at pH 7.4 and 30 degrees Celsius, with DCIP as electron acceptor)


substrate_name: butyraldehyde (at pH 7.4 and 30 degrees Celsius, with DCIP as electron acceptor)


substrate_name: propionaldehyde (at pH 7.4 and 30 degrees Celsius, with DCIP as electron acceptor)


substrate_name: acetaldehyde (at pH 7.4 and 30 degrees Celsius, with DCIP as electron acceptor)


enzyme_display_name: salicylaldehyde dehydrogenase

organism: Pseudomonas putida

substrate_name: Salicylaldehyde


enzyme_display_name: vanillin dehydrogenase

organism: Streptomyces sp. NL15-2K

substrate_name: Vanillin


substrate_name: NAD+


organism: Lysinibacillus sphaericus

substrate_name: NADP+


organism: Rattus norvegicus


substrate_name: NADH


substrate_name: nitrite


organism: Thermus thermophilus


organism: Lathyrus oleraceus


substrate_name: D-glyceraldehyde 3-phosphate


substrate_name: clothianidin


substrate_name: nitenpyram


substrate_name: imidacloprid


organism: Lactiplantibacillus plantarum


substrate_name: oxygen


substrate_name: phosphate


organism: Arachis hypogaea


organism: Triticum aestivum


organism: Hevea brasiliensis


organism: Streptococcus pyogenes


organism: Trypanosoma cruzi


substrate_name: L-glutamate 5-semialdehyde


enzyme_display_name: aspartate-semialdehyde dehydrogenase

substrate_name: L-4-aspartyl phosphate


substrate_name: NADPH


organism: Streptococcus pneumoniae

substrate_name: L-aspartate-semialdehyde


organism: Bos taurus


organism: Oryctolagus cuniculus


organism: Camelus dromedarius


enzyme_display_name: (methyl)glyoxal oxidase

organism: Thermothelomyces thermophilus


substrate_name: glycerol


substrate_name: methylglyoxal


organism: Pseudomonas putida


substrate_name: pyruvate


substrate_name: 3-phospho-D-glyceroyl phosphate


organism: Plasmodium falciparum


substrate_name: NAD+


organism: Saccharomyces cerevisiae


enzyme_display_name: dihydrolipoyl dehydrogenase

organism: Acrididae

substrate_name: Coenzyme A; 2-Oxoglutarate; NAD+

source_license: SABIO-RK terms (free for academic use; see sabiork.h-its.org)


enzyme_display_name: aldehyde dehydrogenase (quinone)

organism: Cupriavidus necator

substrate_name: Butyraldehyde


substrate_name: propionaldehyde


substrate_name: pentanal


substrate_name: acetaldehyde


substrate_name: formaldehyde


enzyme_display_name: abscisic-aldehyde oxidase

organism: Lathyrus oleraceus

substrate_name: abscisic aldehyde


organism: Sus scrofa


substrate_name: NADH


organism: Pseudomonas aeruginosa

substrate_name: octanal


organism: Lucilia sericata

substrate_name: NAD+; 2-Oxoglutarate; Coenzyme A


organism: Geobacillus stearothermophilus

substrate_name: Pyruvate; Thiamine diphosphate


substrate_name: Thiamine diphosphate; Pyruvate


organism: Homo sapiens

substrate_name: Coenzyme A; NAD+; Pyruvate


organism: Pisum sativum

substrate_name: NAD+; Pyruvate; Coenzyme A


organism: Solanum tuberosum


substrate_name: Coenzyme A; Pyruvate; NAD+


substrate_name: Pyruvate; NAD+; Coenzyme A


organism: Corynebacterium glutamicum


organism: Rattus norvegicus


organism: Escherichia coli


substrate_name: NAD+; 4-Hydroxy-2-oxoglutarate; Coenzyme A


substrate_name: 4-Hydroxy-2-oxoglutarate; NAD+; Coenzyme A


organism: Mycobacterium tuberculosis

substrate_name: Pyruvate; Coenzyme A; NAD+


substrate_name: Coenzyme A; 2-Oxopentanoate; NAD+


substrate_name: pyruvate


substrate_name: thiamine diphosphate


organism: Azotobacter vinelandii


substrate_name: NAD+; 4-Methylthio-2-oxobutanoate; Coenzyme A


substrate_name: Coenzyme A; NAD+; 2-Oxoglutarate


substrate_name: NAD+; Coenzyme A; 2-Oxoglutarate


substrate_name: Coenzyme A; 2-Oxoglutarate; NAD+


substrate_name: 2-Oxoglutarate; NAD+; Coenzyme A


substrate_name: 2-Oxoglutarate; Coenzyme A; NAD+


organism: Synechococcus sp. PCC 7002


substrate_name: alpha-Ketovaline; NAD+; Coenzyme A


substrate_name: NAD+; Coenzyme A; alpha-Ketovaline


organism: Bos taurus


substrate_name: Coenzyme A; 4-Methyl-2-oxopentanoate; NAD+


substrate_name: Coenzyme A; NAD+; alpha-Ketovaline


organism: Thauera butanivorans


organism: Acetobacter aceti

substrate_name: acetaldehyde


organism: Gluconobacter sp.


organism: Gluconacetobacter diazotrophicus

substrate_name: acetic acid


organism: Gluconobacter oxydans


organism: Picosynechococcus sp. PCC 7002


organism: Rhizorhabdus wittichii

substrate_name: Butanal


organism: Geobacillus stearothermophilus


organism: Synechocystis sp. PCC 6803


organism: Urocitellus richardsonii


organism: Trametes cinnabarina

substrate_name: glyoxylic acid


substrate_name: methylglyoxal


substrate_name: Glyoxal


substrate_name: glycerol


organism: Arabidopsis thaliana

substrate_name: abscisic aldehyde


substrate_name: benzaldehyde


substrate_name: cinnamaldehyde


enzyme_display_name: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)

substrate_name: pyruvate


enzyme_display_name: Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial


enzyme_display_name: Multifunctional 2-oxoglutarate metabolism enzyme

organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)


substrate_name: magnesium ions


substrate_name: thiamine pyrophosphate


organism: Homo sapiens

substrate_name: alpha-Ketovaline


substrate_name: thiamine diphosphate


enzyme_display_name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial


organism: Phanerodontia chrysosporium


enzyme_display_name: Pyruvate dehydrogenase E1 component

organism: Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534)


organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)

substrate_name: alpha-ketoglutarate


enzyme_display_name: 2-oxoglutarate dehydrogenase E1/E2 component


organism: Escherichia coli

substrate_name: E2p lipoyl domain


organism: Azotobacter vinelandii

substrate_name: lipoyl domain


mutation_signature: recombinant pyruvate dehydrogenase with N-terminal deletion acyl group transfer reaction / recombinant pyruvate dehydrogenase with N-terminal deletion


mutation_signature: recombinant pyruvate dehydrogenase with N-terminal deletion recombinant pyruvate dehydrogenase with N-terminal deletion


substrate_name: 2-oxo-5-hexenoic acid


organism: Pseudomonas putida


organism: Rattus norvegicus


substrate_name: NAD+


substrate_name: Unknown


substrate_name: coenzyme A


substrate_name: L-2-aminoadipate 6-semialdehyde


organism: Sus scrofa


enzyme_display_name: retinal dehydrogenase


substrate_name: acetaldehyde


organism: Gallus gallus

substrate_name: retinal


enzyme_display_name: formaldehyde dehydrogenase

substrate_name: formaldehyde


enzyme_display_name: cinnamoyl-CoA reductase

substrate_name: p-Coumaroyl-CoA


enzyme_display_name: phenylacetaldehyde dehydrogenase


organism: Pseudomonas sp.

substrate_name: formate


enzyme_display_name: long-chain acyl-protein thioester reductase

organism: Photobacterium phosphoreum

substrate_name: tetradecanoyl-CoA


substrate_name: NADPH


enzyme_display_name: coniferyl-aldehyde dehydrogenase

substrate_name: coniferyl aldehyde


substrate_name: NADP+


organism: Acinetobacter baumannii

substrate_name: succinate semialdehyde


enzyme_display_name: glutamyl-tRNA reductase

substrate_name: L-glutamyl-tRNAGlu


enzyme_display_name: aldehyde oxidase

organism: Mesocricetus auratus


substrate_name: benzaldehyde


organism: Escherichia coli K-12


organism: Oryctolagus cuniculus

substrate_name: cinchonidine


enzyme_display_name: pyruvate oxidase

organism: Lactobacillus delbrueckii

substrate_name: pyruvate


substrate_name: phosphate


organism: Lactiplantibacillus plantarum


substrate_name: Unknown


organism: Mus musculus


substrate_name: thiamine diphosphate


organism: Homo sapiens


organism: Bos taurus


organism: Brassica oleracea


substrate_name: alpha-ketoisovaleric acid


enzyme_display_name: pyruvate dehydrogenase (quinone)

organism: Escherichia coli

substrate_name: ferricyanide


substrate_name: NAD+


substrate_name: coenzyme A


substrate_name: acetaldehyde


organism: Arabidopsis thaliana


enzyme_display_name: 2-oxoglutarate synthase

organism: Sulfolobus sp.


enzyme_display_name: pyruvate synthase (ferredoxin)

organism: Chlamydomonas reinhardtii

substrate_name: oxidized ferredoxin 2


substrate_name: CoA


organism: Caldicellulosiruptor bescii

substrate_name: oxidized ferredoxin


substrate_name: glyceraldehyde 3-phosphate


enzyme_display_name: aldehyde ferredoxin oxidoreductase

organism: Aromatoleum aromaticum


substrate_name: phenylacetaldehyde


substrate_name: Oxidized benzyl viologen


organism: Magnetococcus marinus

substrate_name: succinyl-CoA


substrate_name: reduced ferredoxin


organism: Aeropyrum pernix

substrate_name: pyruvate


organism: Citrobacter sp.


organism: Hydrogenobacter thermophilus


enzyme_display_name: aerobic carbon monoxide dehydrogenase

organism: Oligotropha carboxidovorans

substrate_name: Carbon monoxide; Ubiquinone-1; H2O


substrate_name: Carbon monoxide dehydrogenase; 1,4-Benzoquinone


enzyme_display_name: pyruvate synthase

organism: Methanococcus maripaludis

substrate_name: oxaloacetate


enzyme_display_name: anaerobic carbon-monoxide dehydrogenase

organism: Afipia carboxidovorans

substrate_name: methylene blue


enzyme_display_name: anaerobic carbon monoxide dehydrogenase


organism: Archaeoglobus fulgidus

substrate_name: D-glyceraldehyde 3-phosphate


organism: Prosthecochloris vibrioformis f. thiosulfatophilum


organism: Pyrobaculum aerophilum

protein_accession_database: NCBI Protein


substrate_name: benzyl viologen


organism: Pyrococcus furiosus

substrate_name: glutaric dialdehyde


substrate_name: Succinic semialdehyde


substrate_name: phenylpropionaldehyde


substrate_name: Indoleacetaldehyde


substrate_name: acetaldehyde


substrate_name: propionaldehyde


enzyme_display_name: Pyruvate:ferredoxin oxidoreductase

organism: Moorella thermoacetica (strain ATCC 39073 / JCM 9320)

substrate_name: methyl viologen (in the oxidative decarboxylation of pyruvate)


organism: Rhodospirillum rubrum

substrate_name: CO


substrate_name: crotonaldehyde


substrate_name: glyceraldehyde


enzyme_display_name: Tungsten-containing formaldehyde ferredoxin oxidoreductase

organism: Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)

substrate_name: formaldehyde


substrate_name: acetyl-CoA


substrate_name: pyruvate


organism: Pseudomonas putida


enzyme_display_name: formaldehyde dismutase

organism: Methanosarcina barkeri

substrate_name: H2O; Propanal


enzyme_display_name: Acetyl-CoA decarbonylase/synthase complex subunit alpha 1

organism: Methanosarcina barkeri (strain Fusaro / DSM 804)

substrate_name: CO (at 37 degrees Celsius)


enzyme_display_name: Carbon monoxide dehydrogenase large chain

organism: Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)


enzyme_display_name: Carbon monoxide dehydrogenase small chain


enzyme_display_name: Carbon monoxide dehydrogenase medium chain


organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)


enzyme_display_name: 2-oxoacid oxidoreductase (ferredoxin)

organism: Sulfolobus sp.


verification_status: corrected


organism: Thermococcus profundus

substrate_name: coenzyme A


enzyme_display_name: Formaldehyde dismutase

substrate_name: ethanol (at 30 degrees Celsius and pH 7.0)


substrate_name: 1-propanol (at 30 degrees Celsius and pH 7.0)


substrate_name: 1-butanol (at 30 degrees Celsius and pH 7.0)


substrate_name: 1-pentanol (at 30 degrees Celsius and pH 7.0)


substrate_name: cyclohexanol (at 30 degrees Celsius and pH 7.0)


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase subunit beta

organism: Saccharolobus solfataricus


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase subunit alpha


organism: Homo sapiens

substrate_name: Butanal


organism: Aromatoleum aromaticum

substrate_name: acetaldehyde


substrate_name: benzaldehyde


substrate_name: NAD+


substrate_name: Oxidized benzyl viologen


substrate_name: phenylacetaldehyde


organism: Halobacterium salinarum


organism: Sulfurisphaera tokodaii

substrate_name: CoA


organism: Sulfolobus sp


substrate_name: 2-oxoglutarate (at pH 6.8 and 50 degrees Celsius)


enzyme_display_name: Oxalate oxidoreductase subunit delta

substrate_name: oxalate


enzyme_display_name: Oxalate oxidoreductase subunit alpha


enzyme_display_name: Oxalate oxidoreductase subunit beta


substrate_name: pyruvate (at pH 6.8 and 50 degrees Celsius)


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase 1, subunit alpha

organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)

substrate_name: pyruvate


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase 1, subunit beta


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase 2, subunit alpha


organism: Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)

substrate_name: pyruvate (at 80 degrees Celsius)


substrate_name: 2-oxoglutarate (at 80 degrees Celsius)


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase 2, subunit beta


enzyme_display_name: aldehyde ferredoxin oxidoreductase

organism: Thermococcus sp.

substrate_name: acetate


substrate_name: glyceraldehyde


substrate_name: Salicylaldehyde


substrate_name: crotonaldehyde


substrate_name: Indoleacetaldehyde


substrate_name: methyl viologen


substrate_name: benzyl viologen


substrate_name: oxidized ferredoxin


substrate_name: isovalerylaldehyde


substrate_name: acetaldehyde


substrate_name: benzaldehyde


substrate_name: formaldehyde


substrate_name: phenylacetaldehyde


substrate_name: propionaldehyde


organism: Thermococcus litoralis

substrate_name: glyoxylate


substrate_name: pyruvate


substrate_name: indolpyruvate


substrate_name: phenylpyruvate


substrate_name: phenylglyoxalate


substrate_name: hydroxyphenylpyruvate


substrate_name: CoA


substrate_name: isobutyryl-CoA


enzyme_display_name: pyruvate synthase (ferredoxin)


organism: Pyrococcus sp.


substrate_name: phenylglyoxylate


enzyme_display_name: formaldehyde dismutase

substrate_name: Butanal


organism: Methylobacterium sp. FD1


enzyme_display_name: UniProt Q96XT4

source_db: skid

source_license: CC BY 4.0; CC BY-NC-ND 4.0


organism: Pseudomonas putida


substrate_name: ethanol


substrate_name: methanol


organism: Archaeoglobus fulgidus

substrate_name: oxidized ferredoxin


organism: Methanothermobacter thermautotrophicus


organism: Pyrococcus furiosus


enzyme_display_name: carboxylate reductase

organism: Neomoorella thermoacetica


substrate_name: terephthalate


substrate_name: acetate


substrate_name: propanoate


substrate_name: benzoate


substrate_name: acetaldehyde


substrate_name: glyceraldehyde


substrate_name: Salicylaldehyde


substrate_name: crotonaldehyde


substrate_name: indolecetaldehyde


substrate_name: methyl viologen


substrate_name: benzyl viologen


substrate_name: Isovaleraldehyde


substrate_name: benzaldehyde


substrate_name: methanal


substrate_name: phenylacetaldehyde


substrate_name: propanal


substrate_name: Indoleacetaldehyde


organism: Methanosarcina barkeri

substrate_name: CoA


substrate_name: oxidized ferredoxin


substrate_name: pyruvate


organism: Methanococcus maripaludis


substrate_name: oxaloacetate


organism: Peptoclostridium acidaminophilum


substrate_name: Butyraldehyde


substrate_name: DL-glyceraldehyde


substrate_name: propionaldehyde


substrate_name: acetaldehyde


substrate_name: Glutaraldehyde


substrate_name: Butanal


substrate_name: ES-1 ferredoxin


substrate_name: cinnamaldehyde


substrate_name: cinnamate


substrate_name: methyl viologen


organism: Clostridium formicaceticum

substrate_name: Butanoate


substrate_name: propanoate


substrate_name: benzoate


substrate_name: benzaldehyde


substrate_name: propanal


organism: Megalodesulfovibrio gigas


substrate_name: furfural


substrate_name: benzyl viologen


substrate_name: octaldehyde


substrate_name: decylaldehyde


enzyme_display_name: Aldehyde oxidoreductase molybdenum-binding subunit PaoC

organism: Escherichia coli (strain K12)


substrate_name: vanillin


substrate_name: crotonaldehyde


organism: Pseudomonas nitroreducens


substrate_name: Salicylaldehyde


organism: Sulfurisphaera tokodaii


substrate_name: D-glyceraldehyde


substrate_name: Indoleacetaldehyde


substrate_name: acetaldehyde


substrate_name: Indolepyruvate


substrate_name: benzylviologen


enzyme_display_name: Glyceraldehyde dehydrogenase large chain

organism: Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)

substrate_name: propionaldehyde (at 80 degrees Celsius and pH 6.7)


substrate_name: D,L-glyceraldehyde (at 80 degrees Celsius and pH 6.7)


enzyme_display_name: Glyceraldehyde dehydrogenase small chain


enzyme_display_name: Glyceraldehyde dehydrogenase medium chain


organism: Oleidesulfovibrio alaskensis


enzyme_display_name: 2-oxoglutarate synthase

organism: Thermococcus litoralis

substrate_name: oxidized ferredoxin


substrate_name: CoA


substrate_name: phenylpyruvate


substrate_name: p-hydroxyphenylpyruvate


enzyme_display_name: anaerobic carbon monoxide dehydrogenase

substrate_name: CO


substrate_name: methyl viologen


enzyme_display_name: formylmethanofuran dehydrogenase

substrate_name: formylmethanofuran


substrate_name: formate


substrate_name: Formamide


substrate_name: methylformamide


enzyme_display_name: 2-oxoacid oxidoreductase (ferredoxin)

organism: Saccharolobus solfataricus


substrate_name: pyruvate


organism: Thermococcus guaymasensis


organism: Desulfomicrobium sp.


organism: Hydrogenobacter thermophilus


substrate_name: acetyl-CoA


enzyme_display_name: UniProt Q28943

organism: Sus scrofa

substrate_name: NADPH

source_license: CC BY-NC-ND 4.0


substrate_name: Uracil


substrate_name: thymine


enzyme_display_name: Fumarate reductase 1

organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

substrate_name: fumarate


organism: Neomoorella thermoacetica


substrate_name: propionyl-CoA


organism: Methanothrix soehngenii


substrate_name: Salicylaldehyde


organism: Methanosarcina mazei


substrate_name: propionaldehyde


substrate_name: acetaldehyde


enzyme_display_name: DELTA4-3-oxosteroid 5beta-reductase

organism: Digitalis canariensis


substrate_name: progesterone


substrate_name: cortisol


substrate_name: cortexone


enzyme_display_name: dihydropyrimidine dehydrogenase (NADP+)

organism: Cupriavidus necator


substrate_name: NADP+


enzyme_display_name: dihydropyrimidine dehydrogenase (NAD+)

organism: Escherichia coli

substrate_name: H+; Uracil; NADH


enzyme_display_name: dihydrouracil dehydrogenase (NAD(+))


substrate_name: Dihydrothymine


substrate_name: Thymine


enzyme_display_name: acyl-CoA dehydrogenase (NADP+)

organism: Rattus norvegicus


substrate_name: crotonyl-CoA


organism: Bos taurus

substrate_name: trans-crotonyl-CoA


substrate_name: butyryl-CoA


substrate_name: acetyl-CoA


enzyme_display_name: fumarate reductase (NADH)

organism: Ruminobacter amylophilus

substrate_name: NADH


substrate_name: fumarate


organism: Shewanella frigidimarina


organism: Pelophylax lessonae

substrate_name: testosterone


substrate_name: NADPH


substrate_name: Unknown


enzyme_display_name: meso-tartrate dehydrogenase

substrate_name: (+)-tartrate


substrate_name: D-malate


organism: Mycolicibacterium smegmatis


organism: Pseudomonas putida

substrate_name: NAD+


substrate_name: meso-tartrate


organism: Capsella rubella


enzyme_display_name: cucurbitacin DELTA23-reductase

organism: Cucurbita maxima


organism: Sus scrofa

substrate_name: meso-Tartrate; NAD+


organism: Candida albicans


organism: Bufo gargarizans

substrate_name: progesterone


organism: Arabidopsis thaliana


substrate_name: cortisol


substrate_name: cortexone


organism: Homo sapiens

substrate_name: androstenedione


substrate_name: cholestenone


substrate_name: corticosterone


substrate_name: Epitestosterone


substrate_name: aldosterone


substrate_name: cortisone


substrate_name: testosterone


enzyme_display_name: NADH:fumarate oxidoreductase

organism: Klebsiella variicola (strain 342)

substrate_name: NADH


organism: Mus musculus


substrate_name: NADPH


enzyme_display_name: Delta(4)-3-oxosteroid 5beta-reductase


substrate_name: Cortisol


substrate_name: Progesterone


substrate_name: Uracil


organism: Digitalis lanata


organism: Ovis aries


substrate_name: thymine


organism: Digitalis purpurea


enzyme_display_name: NAD-dependent dihydropyrimidine dehydrogenase subunit PreA

organism: Escherichia coli (strain K12)

substrate_name: uracil


substrate_name: DHT


substrate_name: DHU


enzyme_display_name: NAD-dependent dihydropyrimidine dehydrogenase subunit PreT


substrate_name: progesterone


substrate_name: Boldenone


organism: Enterococcus faecalis


substrate_name: cortisol


organism: Escherichia coli

substrate_name: Dihydrothymine


organism: Pyrococcus furiosus

substrate_name: CoA


substrate_name: Ferredoxin


enzyme_display_name: anaerobic carbon monoxide dehydrogenase

organism: Methanosarcina barkeri

substrate_name: 2,3,5-triphenyltetrazolium chloride


substrate_name: methyl viologen


organism: Aeropyrum pernix

substrate_name: pyruvate


organism: Sulfurisphaera tokodaii


enzyme_display_name: formylmethanofuran dehydrogenase

organism: Methanothermobacter thermautotrophicus

substrate_name: oxidized carbamoylviologen


substrate_name: methanofuran


organism: Sus scrofa


substrate_name: NADPH


organism: Bos taurus


substrate_name: NAD+


enzyme_display_name: formaldehyde dismutase

organism: Pseudomonas putida

substrate_name: formaldehyde


substrate_name: Unknown


enzyme_display_name: aspartate-semialdehyde dehydrogenase


organism: Streptococcus pneumoniae


organism: Vibrio cholerae serotype O1


organism: Methanothermobacter wolfeii

substrate_name: N-formylmethanofuran


substrate_name: methylviologen


organism: Trypanosoma cruzi

substrate_name: D-glyceraldehyde 3-phosphate


organism: Mus musculus

substrate_name: D-Glyceraldehyde 3-phosphate; Phosphate; NAD+

source_license: CC BY 4.0; SABIO-RK terms (free for academic use; see sabiork.h-its.org)


organism: Oryctolagus cuniculus

substrate_name: thio-NAD+


organism: Vibrio cholerae


organism: Homo sapiens


enzyme_display_name: UniProt Q3JQY0

organism: Burkholderia pseudomallei


substrate_name: crotonyl-CoA


enzyme_display_name: UniProt Q8Z9U1

organism: Yersinia pestis


enzyme_display_name: UniProt P0AEK4

organism: Escherichia coli

substrate_name: NADH


enzyme_display_name: UniProt Q9BH77

organism: Plasmodium falciparum


enzyme_display_name: UniProt Q7MAW0

organism: Porphyromonas gingivalis


enzyme_display_name: prephenate dehydrogenase

organism: Methanohalophilus mahii

substrate_name: NADP+


enzyme_display_name: UniProt Q8DUW0

organism: Streptococcus mutans


substrate_name: prephenate


organism: Sus scrofa


substrate_name: phosphate


organism: Candida maltosa


enzyme_display_name: 2,5-dioxovalerate dehydrogenase

organism: Pseudomonas putida

substrate_name: alpha-Ketoglutaric semialdehyde


organism: Carthamus tinctorius

substrate_name: crotonyl-[acyl-carrier protein]


enzyme_display_name: prephenate dehydrogenase (NADP+)

organism: Methanothrix harundinacea


substrate_name: L-arogenate


organism: Vigna radiata

substrate_name: Prephenate; NADP+


organism: Nanoarchaeum equitans


substrate_name: NAD+


organism: Acinetobacter calcoaceticus


enzyme_display_name: dihydroorotate dehydrogenase (NADP+)

organism: Bacteria

substrate_name: Orotate


substrate_name: NADPH


organism: Persea americana


substrate_name: Crotonyl-N-acetyl-cysteamine


enzyme_display_name: enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)


organism: Azomonas insignis


organism: Ignicoccus hospitalis


organism: Phaseolus vulgaris


organism: Staphylococcus aureus

substrate_name: Unknown


enzyme_display_name: beta-nitroacrylate reductase

organism: Penicillium atrovenetum


enzyme_display_name: 2-coumarate reductase

organism: Arthrobacter sp.

substrate_name: o-coumarate


organism: Saccharomyces cerevisiae


organism: Plasmodium falciparum

substrate_name: Crotonoyl-CoA; H+; NADH


substrate_name: Butanoyl-CoA; NAD+


enzyme_display_name: UniProt A0A1C9HA64

organism: uncultured bacterium


substrate_name: crotonoyl-CoA


enzyme_display_name: dihydroorotate dehydrogenase (NAD+)

organism: Lactococcus lactis subsp. lactis

substrate_name: L-Dihydroorotate; NAD+


substrate_name: NAD+; L-Dihydroorotate


organism: Enterococcus faecalis


organism: Bacillus subtilis


enzyme_display_name: dihydroorotate dehydrogenase (NAD(+))


substrate_name: L-Dihydroorotate


organism: Corynebacterium glutamicum

substrate_name: prephenate


organism: Bacillus cereus


organism: Clostridium oroticum


organism: Streptomyces collinus


organism: Pleurotus ostreatus


organism: Homo sapiens

substrate_name: (9E)-9-nitrooctadec-9-enoic acid


organism: Ignicoccus hospitalis


organism: Aquifex aeolicus


organism: Yersinia pestis


substrate_name: NADH


enzyme_display_name: Cyclohexadienyl dehydrogenase

organism: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

substrate_name: L-arogenate (at pH 6.6 and 37 degrees Celsius)


substrate_name: prephenate (at pH 6.6 and 37 degrees Celsius)


substrate_name: NAD(+) (at pH 6.6 and 37 degrees Celsius)


organism: Glycine max


organism: Mycolicibacterium smegmatis


organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

substrate_name: NADH (at pH 6.8 and 25 degrees Celsius)


substrate_name: 2-trans-dodecenoyl-CoA (at pH 6.8 and 25 degrees Celsius)


enzyme_display_name: UniProt Q2P9J6

organism: Xanthomonas oryzae

substrate_name: crotonyl-CoA


organism: Burkholderia mallei (strain ATCC 23344)

substrate_name: DD-CoA (with His tag)


enzyme_display_name: Prephenate dehydrogenase

substrate_name: prephenate (at pH 7.9 and 37 degrees Celsius)


substrate_name: NAD(+) (at pH 7.9 and 37 degrees Celsius)


organism: Escherichia coli


substrate_name: NAD+


organism: Spinacia oleracea


organism: Staphylococcus aureus

substrate_name: NADPH


organism: Bacillus subtilis


organism: Methanohalophilus mahii


organism: Streptococcus pneumoniae


organism: Medicago truncatula


organism: Eimeria tenella


organism: Plasmodium falciparum

substrate_name: crotonoyl-CoA


substrate_name: Prephenate


organism: Burkholderia mallei


organism: Yersinia pestis


organism: Homo sapiens

substrate_name: Dodecenoyl-CoA


organism: Burkholderia pseudomallei


organism: Mycolicibacterium smegmatis


enzyme_display_name: Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit

organism: Enterococcus faecalis (strain ATCC 700802 / V583)

substrate_name: orotate


substrate_name: dihydroorotate


substrate_name: NAD(+)


substrate_name: NADH


organism: Mycobacterium tuberculosis


organism: uncultured bacterium pBF1


enzyme_display_name: UniProt P0AEK4

organism: Escherichia coli


substrate_name: But-2-enoyl-[acyl-carrier protein]


organism: uncultured bacterium

substrate_name: prephenate


organism: Bacillus subtilis (strain 168)


enzyme_display_name: Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic

organism: Arabidopsis thaliana


organism: Lactococcus lactis subsp. cremoris (strain MG1363)


enzyme_display_name: UniProt P54616

organism: Bacillus subtilis


organism: Xanthomonas oryzae


enzyme_display_name: Enoyl-[acyl-carrier-protein] reductase [NADH] 1

organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)


organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)


enzyme_display_name: prephenate dehydrogenase (NADP(+))

organism: Ignicoccus hospitalis


enzyme_display_name: prephenate dehydrogenase

organism: Pleurotus ostreatus


organism: Burkholderia mallei


substrate_name: crotonyl-[acyl-carrier protein]


organism: Lactococcus lactis

substrate_name: Orotate


substrate_name: (S)-dihydroorotate


substrate_name: octenoyl-CoA


organism: Staphylococcus aureus

substrate_name: Crotonyl-N-acetyl-cysteamine


substrate_name: dodecenoyl-[Staphylococcus aureus acyl carrier protein]


organism: Cereibacter sphaeroides


organism: Mycobacterium tuberculosis


organism: Vibrio cholerae serotype O1


substrate_name: crotonyl-CoA


substrate_name: NADPH


organism: Bacillus anthracis


substrate_name: NAD+


substrate_name: Unknown


organism: Cupriavidus necator


organism: Burkholderia pseudomallei


substrate_name: crotonyl-[acyl-carrier-protein]


organism: Arabidopsis thaliana


organism: Brassica napus


organism: Archaeoglobus fulgidus


organism: Bacillus subtilis


organism: Rattus norvegicus


organism: Pseudomonas sp.

substrate_name: DELTA1-piperidine 6-carboxylate


organism: Pseudomonas aeruginosa

substrate_name: CoA


enzyme_display_name: retinal dehydrogenase


enzyme_display_name: glutamate-5-semialdehyde dehydrogenase

organism: Escherichia coli

substrate_name: glutamic gamma-semialdehyde


enzyme_display_name: cinnamoyl-CoA reductase

organism: Triticum aestivum

substrate_name: caffeoyl-CoA


enzyme_display_name: formaldehyde dehydrogenase

organism: Pseudomonas putida

substrate_name: aryl alcohol


organism: Bos taurus


enzyme_display_name: salicylaldehyde dehydrogenase


enzyme_display_name: alcohol-forming fatty acyl-CoA reductase (NADPH)

organism: Cavia porcellus


organism: Saccharomyces cerevisiae


organism: Saccharomyces sp.


enzyme_display_name: UniProt P31213

organism: Homo sapiens

substrate_name: androstenedione


substrate_name: progesterone


enzyme_display_name: UniProt P06762

substrate_name: Biliverdin


enzyme_display_name: UniProt P30043


enzyme_display_name: UniProt P72782

organism: Synechocystis sp. PCC 6803


substrate_name: NADH


organism: Sinorhizobium meliloti


enzyme_display_name: cholestenone 5alpha-reductase

organism: Digitalis lanata

substrate_name: H+; Progesterone; NADPH


organism: Macaca fascicularis

substrate_name: testosterone


substrate_name: corticosterone


organism: Rhinella arenarum


organism: Penicillium crustosum


enzyme_display_name: 3-methyleneoxindole reductase

organism: Lathyrus oleraceus


organism: Pseudomonas fluorescens


enzyme_display_name: biliverdin reductase


organism: Salmo salar

substrate_name: NADPH; H+; Biliverdin


substrate_name: biliverdin IXalpha


organism: Synechocystis sp.


organism: Spodoptera frugiperda


organism: Digitalis purpurea


substrate_name: NADPH


enzyme_display_name: Aldo-keto reductase family 1 member C2

substrate_name: (s)-tetralol (oxidation)


substrate_name: benzene dihydrodiol (oxidation)


substrate_name: prostaglandin D2 (reduction)


enzyme_display_name: Aldo-keto reductase family 1 member C1

substrate_name: (s)-tetralol


organism: Macaca fuscata

substrate_name: Camphorquinone


substrate_name: D-xylose


substrate_name: progesterone (reduction)


substrate_name: testosterone (oxidation)


substrate_name: NADP(+)


substrate_name: allopregnanolone (oxidation)


substrate_name: Biliverdin


organism: Pseudomonas putida


substrate_name: glycerol


substrate_name: 5alpha-androstan-3,17-dione (reduction)


substrate_name: NADH


substrate_name: (s)-indan-1-ol (oxidation)


enzyme_display_name: Biliverdin reductase A

organism: Rattus norvegicus

substrate_name: biliverdin (at pH 6.75)


substrate_name: NADH (at pH 6.75)


substrate_name: NADPH (at pH 8.7)


organism: Macaca fuscata fuscata

substrate_name: naphthalene dihydrodiol (at pH 10.0)


substrate_name: benzene dihydrodiol (at pH 10.0)


substrate_name: 3-deoxyglucosone (at pH 7.5)


substrate_name: camphorquinone (at pH 7.5)


substrate_name: methylglyoxal (at pH 7.5)


substrate_name: D-xylose (at pH 7.5)


substrate_name: D-glucose (at pH 7.5)


substrate_name: D-Glyceraldehyde


substrate_name: Camphorquinone


substrate_name: Dihydroxyacetone


substrate_name: Glyceraldehyde 3-phosphate


substrate_name: L-Glyceraldehyde


substrate_name: p-Nitrobenzaldehyde


substrate_name: glycerone phosphate


organism: Homo sapiens


substrate_name: 9alpha,11beta-Prostaglandin F2


substrate_name: Pregnanediol


substrate_name: progesterone (reduction)


enzyme_display_name: 3-oxo-5-alpha-steroid 4-dehydrogenase 2

substrate_name: testosterone


substrate_name: progesterone


substrate_name: androstenedione


substrate_name: corticosterone


substrate_name: cortisol


organism: Solanum lycopersicum


organism: Canis lupus familiaris

substrate_name: naphthalene dihydrodiol (at pH 7.5)


substrate_name: benzene dihydrodiol (at pH 7.5)


substrate_name: D-xylose


substrate_name: 3-deoxyglucosone (at pH 7.5)


substrate_name: camphorquinone (at pH 7.5)


substrate_name: methylglyoxal (at pH 7.5)


enzyme_display_name: 3-oxo-5-alpha-steroid 4-dehydrogenase 1


enzyme_display_name: Steroid 5-alpha-reductase DET2

organism: Arabidopsis thaliana


substrate_name: NADPH


organism: Sus scrofa


substrate_name: D-xylose (at pH 7.5)


organism: Oryctolagus cuniculus


organism: Cavia porcellus

substrate_name: Biliverdin


substrate_name: NADH


substrate_name: Benzene dihydrodiol


organism: Pseudomonas sp.

substrate_name: NAD+


substrate_name: testosterone


enzyme_display_name: 7-dehydrocholesterol reductase

substrate_name: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol (in the AEBS complex assay)


substrate_name: trans-benzene dihydrodiol


organism: Bos taurus


substrate_name: androsterone


substrate_name: Unknown


substrate_name: ergosterol


substrate_name: cortisone


organism: Zea mays


enzyme_display_name: aldehyde oxidase


enzyme_display_name: UniProt P54550

organism: Bacillus subtilis


substrate_name: methotrexate


organism: Callithrix jacchus

substrate_name: Phthalazine


enzyme_display_name: 2-hexadecenal reductase


organism: Novosphingobium aromaticivorans

substrate_name: fluoranthene 2,3-dihydrodiol


substrate_name: chrysene 3,4-dihydrodiol


enzyme_display_name: 2-enoate reductase

organism: Achromobacter sp.


substrate_name: NADPH


organism: Hordeum vulgare

substrate_name: traumatin


organism: Mucor circinelloides


substrate_name: NADP+


organism: Nocardia sp.


organism: Klebsiella pneumoniae

substrate_name: NADH


organism: Gluconobacter oxydans


organism: Heyndrickxia coagulans

substrate_name: trans-cinnamic acid


organism: Lacticaseibacillus casei


organism: Yersinia bercovieri


enzyme_display_name: maleylacetate reductase

organism: Pimelobacter simplex

substrate_name: maleylacetate


organism: Sphingobium chlorophenolicum


organism: Escherichia coli (strain K12)

substrate_name: trans-3,5-cyclohexadiene-1,2-diol (at pH 7.4 and 37 degrees Celsius)


substrate_name: 2-cyclohexen-1-ol (at pH 7.4 and 37 degrees Celsius)


organism: Artemisia annua

substrate_name: beta-ionone


organism: Pseudomonas putida


substrate_name: NAD+


organism: Clostridium acetobutylicum


substrate_name: cis-Toluene dihydrodiol


substrate_name: cis-benzene dihydrodiol


organism: Bacillus subtilis


organism: Cupriavidus necator


organism: Escherichia coli


organism: Clostridium sp.

substrate_name: cinnamate


organism: Macaca fascicularis


organism: Mus musculus

substrate_name: retinal


enzyme_display_name: geissoschizine dehydrogenase

organism: Catharanthus roseus


substrate_name: Geissoschizine


organism: Oryctolagus cuniculus

substrate_name: phenanthridine


enzyme_display_name: protochlorophyllide reductase

organism: Lyngbya majuscula


substrate_name: protochlorophyllide


organism: Chlorobaculum tepidum


substrate_name: Dithionite


organism: Homo sapiens

mutation_signature: recombinant His-tagged truncated enzyme


substrate_name: NADPH


organism: Rhodobacter capsulatus


enzyme_display_name: enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)

organism: Porphyromonas gingivalis


substrate_name: crotonyl-CoA


enzyme_display_name: cis-2-enoyl-CoA reductase (NADPH)


organism: Thermosynechococcus vestitus


enzyme_display_name: trans-2-enoyl-CoA reductase (NADPH)

organism: Mycobacterium tuberculosis


substrate_name: NADH


organism: Chlamydomonas reinhardtii


organism: Marchantia paleacea


organism: Escherichia coli (strain K12)


enzyme_display_name: UniProt P42593


organism: Cavia porcellus


organism: Synechocystis sp.


substrate_name: protochlorophyllide a


organism: Gloeobacter violaceus


enzyme_display_name: Fatty acid synthase

substrate_name: acetyl-CoA


substrate_name: malonyl-CoA


substrate_name: butanoyl-CoA


organism: Staphylococcus aureus

substrate_name: But-2-enoyl-[acyl-carrier protein]


substrate_name: Dodecenoyl-CoA


organism: Leptolyngbya boryana


organism: Bos taurus

substrate_name: lithocholic acid


substrate_name: chenodeoxycholic acid


substrate_name: cholic acid


substrate_name: taurocholic acid


substrate_name: taurolithocholic acid


substrate_name: deoxycholic acid


substrate_name: taurochenodeoxycholic acid


enzyme_display_name: UniProt Q9FEW9

organism: Solanum lycopersicum


enzyme_display_name: UniProt Q9FUP0

organism: Arabidopsis thaliana


substrate_name: Methyl vinyl ketone


enzyme_display_name: 2'-hydroxyisoflavone reductase

organism: Cicer arietinum


substrate_name: NADPH


organism: Avena sativa


organism: Synechocystis sp. PCC 6803

substrate_name: protochlorophyllide


enzyme_display_name: Trans-2-enoyl-CoA reductase

organism: Euglena gracilis

substrate_name: trans-2-hexenoyl-CoA (in the presence of NADH)


enzyme_display_name: Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI

organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)

substrate_name: NADPH (with DD-ACP at 25 degrees Celsius and pH 7.8)


enzyme_display_name: arogenate dehydrogenase

organism: Stutzerimonas stutzeri

substrate_name: prephenate


substrate_name: NAD+


substrate_name: L-arogenate


substrate_name: Unknown


organism: Mus musculus

substrate_name: malonyl-CoA


substrate_name: acetyl-CoA


enzyme_display_name: 12-oxophytodienoate reductase

organism: Zea mays


substrate_name: 12-oxophytodienoic acid


substrate_name: NADH


organism: Thermosynechococcus vestitus

substrate_name: monovinyl protochlorophyllide a


organism: Homo sapiens


enzyme_display_name: trans-2-enoyl-CoA reductase (NAD+)

organism: Mycolicibacterium smegmatis


substrate_name: hexadecenoyl-CoA


organism: Pseudomonas aeruginosa


organism: Lathyrus oleraceus


organism: Phenylobacterium immobile


organism: Pseudomonas flexibilis


organism: Streptomyces phaeochromogenes


substrate_name: NAD+; L-Arogenate


enzyme_display_name: biochanin-A reductase

organism: Fusarium solani-melongenae

substrate_name: Biochanin A


organism: Actinoplanes missouriensis


enzyme_display_name: alpha-santonin 1,2-reductase

organism: Pseudomonas cichorii


substrate_name: alpha-santonin


enzyme_display_name: xanthommatin reductase

organism: Drosophila melanogaster

substrate_name: Xanthommatin


organism: Medicago sativa


enzyme_display_name: Prostaglandin reductase-3


enzyme_display_name: Trans-2-enoyl-CoA reductase [NADH]

organism: Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)

substrate_name: NAD


substrate_name: dodecenoyl-CoA


substrate_name: hexenoyl-CoA


substrate_name: NADP


enzyme_display_name: 12-oxophytodienoate reductase 2

organism: Arabidopsis thaliana


substrate_name: crotonyl-CoA (at pH 6.2 and 30 degrees Celsius)


organism: Clostridium acetobutylicum


organism: Burkholderia mallei (strain ATCC 23344)

substrate_name: DD-CoA (with His tag)


organism: Euglena gracilis

substrate_name: crotonyl-CoA


enzyme_display_name: Cyclohexadienyl dehydrogenase

organism: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

substrate_name: L-arogenate (at pH 6.6 and 37 degrees Celsius)


substrate_name: prephenate (at pH 6.6 and 37 degrees Celsius)


substrate_name: NAD(+) (at pH 6.6 and 37 degrees Celsius)


organism: Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / IAM 19013 / LMG 5710 / NBRC 13948 / NRRL B-527 / VKM B-1787 / 2291 / W)

substrate_name: NAD (at pH 6.2 and 25 degrees Celsius)


organism: Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

substrate_name: NADH


enzyme_display_name: 12-oxophytodienoate reductase 1

organism: Solanum lycopersicum

substrate_name: N-ethylmaleimide (at pH 7.0 and 25 degrees Celsius)


substrate_name: maleic acid (at pH 7.0 and 25 degrees Celsius)


substrate_name: OPDA (at pH 7.0 and 25 degrees Celsius)


enzyme_display_name: 15-oxoprostaglandin 13-reductase

organism: Mus musculus

substrate_name: 15-Keto-prostaglandin E1


substrate_name: 15-Keto-prostaglandin F1alpha


substrate_name: 15-Keto-prostaglandin F2alpha


substrate_name: NADPH


enzyme_display_name: Prostaglandin reductase 2


enzyme_display_name: Prostaglandin reductase 1

organism: Homo sapiens


substrate_name: 15-oxoprostaglandin E1


substrate_name: 15-oxoprostaglandin E2


substrate_name: 15-oxoprostaglandin F1alpha


organism: Sus scrofa


enzyme_display_name: trans-2-enoyl-CoA reductase (NAD(+))


enzyme_display_name: 12-oxophytodienoate reductase 3


substrate_name: cyclohexenone


organism: Cavia porcellus


enzyme_display_name: Isoflavone reductase


substrate_name: NADP(+)


substrate_name: 15-oxoprostaglandin F2alpha


substrate_name: leukotriene B4


organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

substrate_name: crotonyl-CoA


organism: Treponema denticola


substrate_name: 15-ketoprostaglandin E1


substrate_name: 15-ketoprostaglandin A1


substrate_name: 15-ketoprostaglandin F2alpha


substrate_name: 15-ketoprostaglandin B1


substrate_name: 15-ketoprostaglandin E2


substrate_name: NADH


substrate_name: nicotinamide hypoxanthine dinucleotide


substrate_name: 15-ketoprostaglandin F1alpha


organism: Escherichia coli

substrate_name: NADPH


organism: Rattus norvegicus

substrate_name: acrolein


substrate_name: crotonaldehyde


substrate_name: alpha-methylcinnamaldehyde


substrate_name: cinnamaldehyde


substrate_name: chalcone


substrate_name: benzylidene acetone


substrate_name: methylvinylketone


substrate_name: ethylvinylketone


enzyme_display_name: dihydropyrimidine dehydrogenase (NADP+)

organism: Bos taurus


substrate_name: Uracil


substrate_name: NADP+


substrate_name: crotonyl-CoA


substrate_name: hexanoyl-CoA


substrate_name: 15-ketoprostaglandin E2


substrate_name: 6,15-diketo-prostaglandin F1alpha


enzyme_display_name: Enoyl-[acyl-carrier-protein] reductase [NADH] 1

organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)


organism: Alcaligenes faecalis


substrate_name: NAD+


organism: Comamonas testosteroni


enzyme_display_name: UniProt Q46381


substrate_name: phenyl propenyl ketone


substrate_name: cinnamoylthiophene


enzyme_display_name: protochlorophyllide reductase

organism: Hordeum vulgare

substrate_name: NADPH


substrate_name: protochlorophyllide


substrate_name: 15-ketoprostaglandin E


substrate_name: NADH


enzyme_display_name: trans-2-enoyl-CoA reductase (NAD+)


enzyme_display_name: precorrin-6A reductase

organism: Pseudomonas denitrificans (nom. rej.)


enzyme_display_name: zeatin reductase

organism: Phaseolus vulgaris

substrate_name: trans-zeatin


enzyme_display_name: 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)

organism: Rhodobacter capsulatus

substrate_name: 3,8-divinyl chlorophyllide a


substrate_name: 3,8-divinyl protochlorophyllide a


enzyme_display_name: DELTA14-sterol reductase

organism: Zea mays


substrate_name: 15-keto-prostaglandin E2


enzyme_display_name: prephenate dehydrogenase

organism: Bacillus subtilis

substrate_name: prephenate


enzyme_display_name: 2'-hydroxydaidzein reductase

organism: Glycine max


organism: Vitis bellula

substrate_name: cyanidin


substrate_name: pelargonidin


substrate_name: delphinidin


organism: Camellia sinensis


enzyme_display_name: arogenate dehydrogenase (NADP+)

organism: Synechocystis sp. PCC 6803

substrate_name: NADP+


substrate_name: L-arogenate


substrate_name: Unknown


enzyme_display_name: 2-alkenal reductase [NAD(P)+]

organism: Artemisia annua


substrate_name: artemisinic aldehyde


organism: Sorghum bicolor


organism: Euglena gracilis


enzyme_display_name: 2-alkenal reductase [NAD(P)(+)]

organism: Cucumis sativus


substrate_name: propenal


organism: Mangifera indica


organism: Nicotiana sylvestris


substrate_name: crotonaldehyde


substrate_name: NADPH


organism: Synechocystis sp.


enzyme_display_name: arogenate dehydrogenase [NAD(P)+]

organism: Sediminispirochaeta smaragdinae


organism: Acinetobacter calcoaceticus


enzyme_display_name: NADPH-dependent oxidoreductase 2-alkenal reductase

organism: Arabidopsis thaliana


organism: Vigna radiata

substrate_name: L-Arogenate; NADP+


substrate_name: decyl-plastoquinone


organism: Zea mays


enzyme_display_name: 1,2-dihydrovomilenine 19,20-reductase

organism: Rauvolfia serpentina

substrate_name: Vomilenine

mutation_signature: N-terminally truncated enzyme


enzyme_display_name: 1,2-Dihydrovomilenine reductase


substrate_name: 9-oxo-10(E),12(Z)-octadecadienoic acid


substrate_name: 13-oxo-9(Z),11(E)-octadecadienoic acid


substrate_name: vomilenine


substrate_name: traumatin


enzyme_display_name: Prostaglandin reductase 1

organism: Sus scrofa


substrate_name: NADH


substrate_name: p-coumaryl aldehyde


substrate_name: coniferyl aldehyde


substrate_name: arogenate


substrate_name: NADP+


substrate_name: prephenate


enzyme_display_name: Arogenate dehydrogenase 2, chloroplastic


organism: Homo sapiens


substrate_name: 15-oxoprostaglandin E1


substrate_name: 15-oxoprostaglandin E2


substrate_name: 15-oxoprostaglandin F1alpha


substrate_name: delphinidin


substrate_name: cyanidin


substrate_name: pelargonidin


organism: Vitis bellula


substrate_name: propenal


substrate_name: Diamide


organism: Rauvolfia tetraphylla


organism: Cavia porcellus


substrate_name: 15-oxoprostaglandin F2alpha


substrate_name: leukotriene B4


substrate_name: NADPH


substrate_name: NADH


substrate_name: Cyanidin


enzyme_display_name: arogenate dehydrogenase (NADP(+))

substrate_name: L-Arogenate


substrate_name: Prephenate


substrate_name: NADP(+)


organism: Medicago truncatula


organism: Bos taurus


substrate_name: pyruvate


enzyme_display_name: UniProt E4N096

organism: Kitasatospora setae


substrate_name: crotonyl-CoA


organism: Brassica napus

substrate_name: crotonyl-[acyl-carrier protein]


enzyme_display_name: aldehyde oxidase

substrate_name: benzaldehyde


substrate_name: phenanthridine


enzyme_display_name: crotonyl-CoA reductase

organism: Clostridioides difficile

substrate_name: butyryl-CoA


substrate_name: Ferredoxin


enzyme_display_name: crotonyl-CoA carboxylase/reductase


enzyme_display_name: (+)-pulegone reductase

organism: Mentha x piperita

substrate_name: Unknown


enzyme_display_name: Crotonyl-CoA carboxylase/reductase

organism: Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)

substrate_name: NADPH (in the reductive carboxylation assay)


substrate_name: ethylmalonyl-CoA (in the oxidative decarboxylation assay)


substrate_name: trans-crotonyl-CoA


substrate_name: NADPH


organism: Streptomyces sp.


substrate_name: cinnamoyl-CoA


substrate_name: acryloyl-CoA (in the reductive carboxylation assay)


substrate_name: (+)-pulegone


enzyme_display_name: acrylyl-CoA reductase (NADPH)

organism: Sulfolobus tokodaii


substrate_name: acryloyl-CoA


enzyme_display_name: Trans-2-enoyl-CoA reductase

organism: Euglena gracilis

substrate_name: trans-2-hexenoyl-CoA (in the presence of NADH)


enzyme_display_name: Crotonyl-CoA reductase

organism: Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)

substrate_name: NADP (at 30 degrees Celsius and at pH 7.5)


substrate_name: crotonyl-CoA (at 30 degrees Celsius and at pH 7.5)


substrate_name: crotonyl-CoA


enzyme_display_name: (-)-isopiperitenone reductase

substrate_name: (-)-isopiperitenone


organism: Sulfurisphaera tokodaii


organism: Streptomyces collinus

substrate_name: crotonyl-CoA (with NADP at pH 7.5)


organism: Escherichia coli

substrate_name: crotonyl CoA


enzyme_display_name: prephenate dehydrogenase


substrate_name: NAD+; Pyruvate; Coenzyme A


substrate_name: NAD+


substrate_name: prephenate


organism: Mentha piperita


enzyme_display_name: acrylyl-CoA reductase (NADH)

organism: Clostridium kluyveri


substrate_name: ethyl vinyl ketone


substrate_name: acrolein


substrate_name: N-acetyl-S-acryloylcysteamine


organism: Cereibacter sphaeroides

substrate_name: acrylyl-CoA


substrate_name: NADPH


enzyme_display_name: Acryloyl-CoA reductase (NADH)

organism: Anaerotignum propionicum

substrate_name: acryloyl-CoA (with NADH as electron acceptor at pH 7.5 and 25 degrees Celsius)


substrate_name: NADH (at pH 7.5 and 25 degrees Celsius)


substrate_name: propionyl-CoA (with of ferricenium hexafluorophosphate as electron acceptor at pH 7.5 and 25 degrees Celsius)


substrate_name: butyryl-CoA (with of ferricenium hexafluorophosphate as electron acceptor at pH 7.5 and 25 degrees Celsius)


substrate_name: 3-buten-2-one (with NADH as electron acceptor at pH 7.5 and 25 degrees Celsius)


enzyme_display_name: dihydrolipoyl dehydrogenase

organism: Homo sapiens

substrate_name: Pyruvate; NAD+; Coenzyme A


substrate_name: Unknown


organism: Metallosphaera sedula

substrate_name: acryloyl-CoA


organism: Ruegeria pomeroyi


organism: Artemisia annua

substrate_name: (+)-carvone


substrate_name: NADH


substrate_name: artemisinic aldehyde


enzyme_display_name: UniProt P61431

organism: Staphylococcus aureus


enzyme_display_name: acryloyl-CoA reductase (NADH)

organism: Clostridium propionicum


substrate_name: Propanoyl-CoA


substrate_name: butanoyl-CoA


enzyme_display_name: oxalate oxidase

organism: Hordeum vulgare

substrate_name: oxalic acid


substrate_name: oxalate


enzyme_display_name: artemisinic aldehyde Delta(11(13)) reductase


enzyme_display_name: 2-alkenal reductase (NADP+)

organism: Plagiochasma appendiculatum

substrate_name: 4-coumaryl aldehyde


substrate_name: caffeoyl aldehyde


substrate_name: coniferyl aldehyde


substrate_name: 5-hydroxyconiferyl aldehyde


substrate_name: crotonyl-N-acetylcysteamine


substrate_name: acrylyl-CoA


organism: Rattus norvegicus

substrate_name: NADPH


organism: Nicotiana tabacum


substrate_name: (S)-carvone


enzyme_display_name: chanoclavine-I aldehyde reductase

organism: Aspergillus fumigatus

substrate_name: chanoclavine-I aldehyde


substrate_name: Unknown


substrate_name: trans-cinnamaldehyde


substrate_name: (S)-pulegone


enzyme_display_name: 2-alkenal reductase (NADP(+)-dependent)

substrate_name: 2-methylpentenal (at pH 5.4)


organism: uncultured bacterium pBF1

substrate_name: crotonyl-CoA


enzyme_display_name: 2-haloacrylate reductase

organism: Burkholderia sp.


enzyme_display_name: UDP-N-acetylmuramate dehydrogenase

organism: Escherichia coli


substrate_name: alpha-NADPH


enzyme_display_name: Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL

organism: Bacillus subtilis (strain 168)


enzyme_display_name: 2-alkenal reductase (NADP(+))

substrate_name: (R)-pulegone


substrate_name: UDP-N-acetylenolpyruvylglucosamine


organism: Mycobacterium tuberculosis


organism: Streptococcus pneumoniae


organism: Enterobacter cloacae


enzyme_display_name: pyruvate oxidase

organism: Lactiplantibacillus plantarum

substrate_name: pyruvate


substrate_name: arsenate


organism: Lathyrus oleraceus


enzyme_display_name: indole-3-acetaldehyde oxidase


enzyme_display_name: formylmethanofuran dehydrogenase

organism: Methanosarcina barkeri

substrate_name: formylmethanofuran


substrate_name: N-Furfurylformamide


enzyme_display_name: enoyl-[acyl-carrier-protein] reductase

organism: Homo sapiens


organism: Methanothermobacter thermautotrophicus

substrate_name: methylviologen


organism: Staphylococcus aureus


organism: Methanothermobacter wolfeii

substrate_name: formate


enzyme_display_name: butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)

organism: Clostridioides difficile

substrate_name: butanoyl-CoA


enzyme_display_name: butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin)


enzyme_display_name: 2-methylene-furan-3-one reductase

organism: Fragaria x ananassa


enzyme_display_name: anaerobic carbon monoxide dehydrogenase

organism: Methanosarcina thermophila

substrate_name: Trichloroethylene


enzyme_display_name: UniProt P9WGR1


substrate_name: NADH


organism: Streptomyces collinus


organism: Acidaminococcus fermentans


organism: Fragaria ananassa


substrate_name: NADPH


organism: Fragaria vesca


enzyme_display_name: meromycolic acid enoyl-[acyl-carrier-protein] reductase

organism: Mycobacterium tuberculosis

substrate_name: Unknown


enzyme_display_name: chlorobenzene dihydrodiol dehydrogenase

organism: Xanthobacter flavus

substrate_name: 3,6-dichlorobenzene cis-dihydrodiol


substrate_name: NAD+


substrate_name: benzene cis-dihydrodiol


enzyme_display_name: hydroxycinnamoyl-CoA reductase

organism: Malus domestica


substrate_name: trans-feruloyl-CoA


substrate_name: trans-2-octenoyl-[acyl-carrier protein]


organism: Solanum lycopersicum


enzyme_display_name: UniProt Q16698


organism: Vitis vinifera

substrate_name: cyanidin (at pH 7.5 and 30 degrees Celsius)


substrate_name: crotonoyl-CoA


enzyme_display_name: 7-dehydrocholesterol reductase

organism: Mus musculus


enzyme_display_name: 8-oxogeranial reductase

organism: Swertia mussotii


enzyme_display_name: (S)-8-oxocitronellyl enol synthase

organism: Antirrhinum majus


organism: Homo sapiens


enzyme_display_name: (S)-8-oxocitronellyl enol synthase ISY2

organism: Nepeta racemosa


organism: Catharanthus roseus


enzyme_display_name: acrylate reductase

organism: Vibrio harveyi

substrate_name: methacrylate


substrate_name: Acrylate


organism: Plantago major


enzyme_display_name: aspartate-semialdehyde dehydrogenase

organism: Methanocaldococcus jannaschii

substrate_name: H+; 4-Phospho-L-aspartate; NADPH


substrate_name: NADP+; L-Aspartate 4-semialdehyde; Phosphate


organism: Pseudomonas aeruginosa

substrate_name: NADP+; Phosphate; L-Aspartate 4-semialdehyde


organism: Vibrio cholerae

substrate_name: Phosphate; L-Aspartate 4-semialdehyde; NADP+


organism: Aspergillus nidulans

substrate_name: Phosphate; NAD+; D-Glyceraldehyde 3-phosphate


organism: Oncorhynchus mykiss


organism: Oryctolagus cuniculus

substrate_name: NAD+; Phosphate; D-Glyceraldehyde 3-phosphate


organism: Oryza sativa

substrate_name: D-Glyceraldehyde 3-phosphate; NAD+; Phosphate


organism: Pinus sylvestris

substrate_name: NAD+; D-Glyceraldehyde 3-phosphate; Phosphate


organism: Pisum sativum

substrate_name: D-Glyceraldehyde 3-phosphate; Phosphate; NAD+


organism: Rattus norvegicus


organism: Amborella trichopoda


organism: Entamoeba histolytica

substrate_name: NADH; H+; 3-Phospho-D-glyceroyl phosphate


organism: Escherichia coli


organism: Geobacillus stearothermophilus


organism: Homo sapiens

substrate_name: Phosphate; D-Glyceraldehyde 3-phosphate; NAD+


organism: Jaculus orientalis


organism: Mus musculus


enzyme_display_name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

organism: Spinacia oleracea

substrate_name: H+; 3-Phospho-D-glyceroyl phosphate; NADPH


organism: Sulfolobus solfataricus


enzyme_display_name: 2,5-dioxovalerate dehydrogenase

organism: Acinetobacter baylyi

substrate_name: H2O; 2,5-Dioxopentanoate; NADP+


organism: Halobacterium volcanii

substrate_name: NADP+; 2,5-Dioxopentanoate; H2O


organism: Pseudomonas putida

substrate_name: 2,5-Dioxopentanoate; NADP+; H2O


organism: Bacillus subtilis

substrate_name: NAD+; Coenzyme A; 2-Methyl-3-oxopropanoate


organism: Saccharomyces cerevisiae


substrate_name: H+; NADH; 3-Phospho-D-glyceroyl phosphate


organism: Streptococcus mutans


organism: Streptomyces arenae


organism: Clostridium beijerinckii

substrate_name: Acetyl-CoA; H+; NADH


organism: Thermus thermophilus

substrate_name: Coenzyme A; NAD+; Acetaldehyde


organism: Arabidopsis thaliana

substrate_name: NADPH; H+; 4-Phospho-L-aspartate


substrate_name: 4-Phospho-L-malate; NADPH; H+


organism: Escherichia coli

substrate_name: L-Aspartate 4-semialdehyde; Phosphate; NADP+


organism: Haemophilus influenzae

substrate_name: Phosphate; NADP+; L-Aspartate 4-semialdehyde


enzyme_display_name: L-galactonolactone dehydrogenase

organism: Triticum aestivum


organism: Ipomoea batatas

substrate_name: L-galactono-gamma-lactone


organism: Solanum tuberosum


substrate_name: G3P (at pH 8 and 26 degrees Celsius)


organism: Thermotoga maritima

substrate_name: NAD+; D-Glyceraldehyde 3-phosphate; Arsenate


organism: Trichoderma koningii

substrate_name: NAD+; Phosphate; D-Glyceraldehyde 3-phosphate


substrate_name: D-Glyceraldehyde 3-phosphate; Phosphate; NAD+


organism: Trypanosoma brucei

substrate_name: Phosphate; D-Glyceraldehyde 3-phosphate; NAD+


substrate_name: NAD+; D-Glyceraldehyde 3-phosphate; Phosphate


enzyme_display_name: retinal dehydrogenase

organism: Mus musculus

substrate_name: all-trans-Retinal; H2O; NAD+


enzyme_display_name: Retinal dehydrogenase 2

organism: Rattus norvegicus

substrate_name: free retinal


enzyme_display_name: glutamate-5-semialdehyde dehydrogenase

organism: Pseudomonas aeruginosa

substrate_name: L-Glutamate 5-semialdehyde; Phosphate; NAD+


enzyme_display_name: cinnamoyl-CoA reductase

substrate_name: H+; Feruloyl-CoA; NADPH


substrate_name: Feruloyl-CoA; H+; NADPH


organism: Homo sapiens


substrate_name: phenazine methosulfate


enzyme_display_name: Fumarate reductase (cytochrome)

organism: Shewanella frigidimarina (strain NCIMB 400)

substrate_name: fumarate (in the presence of methyl viologen)


substrate_name: succinate (in the presence of 2,6-dichlorophenol-indophenol)


enzyme_display_name: fumarate reductase (cytochrome)

organism: Shewanella frigidimarina

substrate_name: fumarate


substrate_name: fumarate (at pH 6.0 with methyl viologen as electron donor)


substrate_name: Coenzyme A; NAD+; (S)-Methylmalonate semialdehyde


enzyme_display_name: carboxylate reductase (NADP+)

organism: Neurospora crassa

substrate_name: benzoyladenosine 5'-monophosphate


organism: Ctenopharyngodon idella

substrate_name: H2O; NAD+; Acetaldehyde


substrate_name: H2O; NAD+; L-2-Aminoadipate 6-semialdehyde


organism: Rhodococcus sp. (in: high G+C Gram-positive bacteria)


organism: Coccomyxa subellipsoidea


enzyme_display_name: UniProt P36551

substrate_name: Coproporphyrinogen-III


substrate_name: Harderoporphyrinogen


enzyme_display_name: UniProt P32397

organism: Bacillus subtilis

substrate_name: protoporphyrinogen-IX


enzyme_display_name: UniProt P50336

substrate_name: protoporphyrinogen IX


enzyme_display_name: UniProt O24164

organism: Nicotiana tabacum


enzyme_display_name: bilirubin oxidase

organism: Thermosediminibacter oceani

substrate_name: syringaldazine


substrate_name: bilirubin


organism: Thermobaculum terrenum


enzyme_display_name: UniProt P07872

substrate_name: octanoyl-CoA


enzyme_display_name: Acyl-coenzyme A oxidase 3, peroxisomal

organism: Arabidopsis thaliana

substrate_name: lauroyl-CoA


organism: Arachis hypogaea

substrate_name: NADP+; D-Glyceraldehyde 3-phosphate; H2O


organism: Clostridium acetobutylicum


organism: Pisum sativum

substrate_name: D-Glyceraldehyde 3-phosphate; NAD+; Arsenate


organism: Streptococcus mutans


organism: Streptococcus pyogenes

substrate_name: D-Glyceraldehyde 3-phosphate; NADP+; H2O


enzyme_display_name: (S)-8-oxocitronellyl enol synthase

organism: Digitalis lanata


enzyme_display_name: abscisic-aldehyde oxidase

substrate_name: H2O; Abscisic aldehyde; O2


enzyme_display_name: pyruvate oxidase

organism: Lactobacillus plantarum

substrate_name: Pyruvate; Phosphate; O2


enzyme_display_name: oxalate oxidase

organism: Hordeum vulgare

substrate_name: O2; Oxalate


enzyme_display_name: indole-3-acetaldehyde oxidase

substrate_name: Indole-3-acetaldehyde; H2O; O2


organism: Corynebacterium glutamicum

substrate_name: Pyruvate; 2,6-Dichloroindophenol


enzyme_display_name: dihydrolipoyl dehydrogenase

organism: Enterococcus faecalis

substrate_name: NAD+; Coenzyme A; Pyruvate


organism: Homo sapiens

substrate_name: 4-Trimethylammoniobutanal; H2O; NAD+


organism: Rattus norvegicus

substrate_name: 4-Trimethylammoniobutanal; NAD+; H2O


enzyme_display_name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)

organism: Bacillus subtilis

substrate_name: NAD+; Phosphate; D-Glyceraldehyde 3-phosphate


organism: Methanothermus fervidus

substrate_name: Phosphate; NAD+; D-Glyceraldehyde 3-phosphate


organism: Synechocystis sp.

substrate_name: NAD+; D-Glyceraldehyde 3-phosphate; Phosphate


enzyme_display_name: fluoroacetaldehyde dehydrogenase

organism: Streptomyces cattleya

substrate_name: Fluoroacetaldehyde; H2O; NAD+


enzyme_display_name: aldehyde oxidase

organism: Arabidopsis thaliana

substrate_name: H2O; Heptanal; 2,6-Dichloroindophenol


substrate_name: 2,6-Dichloroindophenol; Heptanal; H2O


organism: Cavia porcellus

substrate_name: 6-Deoxypenciclovir; O2; H2O


organism: Macaca fascicularis


organism: Oryctolagus cuniculus

substrate_name: H2O; O2; 6-Deoxypenciclovir


enzyme_display_name: acyl-CoA oxidase

organism: Candida tropicalis

substrate_name: O2; Stearoyl-CoA


substrate_name: Octanoyl-CoA; O2


substrate_name: Lauroyl-CoA; O2


substrate_name: O2; Palmitoyl-CoA


organism: Synechococcus elongatus

substrate_name: H+; NADPH; Oleoyl-[acyl-carrier protein]


enzyme_display_name: Fatty acyl-CoA reductase 2, chloroplastic

substrate_name: hexadecanoyl-[ACP] (at pH 6 and 30 degrees Celsius)


enzyme_display_name: Fatty acyl-CoA reductase 6, chloroplastic

substrate_name: C16:0-ACP (at pH 7 and 30 degrees Celsius)


organism: Thermus thermophilus

substrate_name: Propanal; NAD+; Coenzyme A


organism: Bos taurus


substrate_name: m-Nitrobenzaldehyde; NAD+; H2O


organism: Sulfolobus solfataricus

substrate_name: Glyceraldehyde 3-phosphate; H2O; NADP+


organism: Thermoproteus tenax

substrate_name: H2O; NADP+; D-Glyceraldehyde 3-phosphate


organism: Zea mays

substrate_name: D-Glyceraldehyde 3-phosphate; NADP+; H2O


organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

substrate_name: GAP (at 70 degrees Celsius)


enzyme_display_name: L-2-aminoadipate reductase

organism: Saccharomyces cerevisiae

substrate_name: ATP; L-2-Aminoadipate


organism: Pseudomonas putida

substrate_name: 4-Hydroxybenzaldehyde; NAD+; H2O


enzyme_display_name: dihydrouracil oxidase

organism: Rhodotorula glutinis

substrate_name: dihydrouracil


substrate_name: Dihydrothymine


substrate_name: Unknown


organism: Glutamicibacter nicotianae

substrate_name: octanoyl-CoA


substrate_name: hexanoyl-CoA


substrate_name: butyryl-CoA


enzyme_display_name: bilirubin oxidase

organism: Bacillus pumilus


organism: Rattus norvegicus

substrate_name: Bilirubin; O2


substrate_name: bilirubin


organism: Aspergillus oryzae


organism: Arabidopsis thaliana

substrate_name: stearoyl-CoA


substrate_name: myristoyl-CoA


enzyme_display_name: tryptophan alpha,beta-oxidase

organism: Chromobacterium violaceum

substrate_name: L-Tryptophan; O2


substrate_name: pentagastrin


substrate_name: L-Tryptophanamide


substrate_name: L-tryptophan


substrate_name: N-Acetyl-L-tryptophanamide


substrate_name: N-acetyl-L-tryptophan


organism: Digitalis purpurea


enzyme_display_name: glutamyl-tRNA reductase

organism: Escherichia coli

substrate_name: H+; L-Glutamyl-tRNA(Glu); NADPH


enzyme_display_name: erythrose-4-phosphate dehydrogenase

substrate_name: H2O; D-Erythrose 4-phosphate; NAD+


organism: Geobacillus stearothermophilus

substrate_name: D-Erythrose 4-phosphate; NAD+; H2O


organism: Clostridium kluyveri

substrate_name: Succinate-semialdehyde


enzyme_display_name: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)

organism: Azoarcus evansii

substrate_name: H2O; NADP+; 3,4-Dehydroadipyl-CoA semialdehyde


organism: Mycobacterium tuberculosis

substrate_name: NADP+; H2O; Succinate semialdehyde


substrate_name: conjugated Bilirubin; O2


organism: Pyricularia oryzae


organism: Zea mays

substrate_name: hexanoyl-CoA


enzyme_display_name: protoporphyrinogen oxidase

organism: Megalodesulfovibrio gigas

substrate_name: protoporphyrinogen-IX


enzyme_display_name: tetrahydroberberine oxidase

organism: Berberis stolonifera

substrate_name: (S)-tetrahydroberberine


organism: Aquifex aeolicus


substrate_name: dodecanoyl-CoA


organism: Haemonchus contortus

substrate_name: palmitoyl-CoA


organism: Coptis japonica


organism: Coscinium fenestratum


organism: Thalictrum minus var. hypoleucum


enzyme_display_name: (S)-8-oxocitronellyl enol synthase

organism: Selaginella moellendorffii


organism: Albifimbria verrucaria


substrate_name: ferrocyanide


organism: Bacillus subtilis

substrate_name: protoporphyrinogen IX


substrate_name: p-phenylenediamine


substrate_name: ditaurobilirubin


organism: Escherichia coli (strain K12)

substrate_name: coproporphyrinogen-III (at pH 6 at 37 degrees Celsius)


substrate_name: bilirubin


enzyme_display_name: coproporphyrinogen oxidase

organism: Homo sapiens

substrate_name: Coproporphyrinogen-III


enzyme_display_name: UniProt P56601

organism: Myxococcus xanthus


organism: Catharanthus roseus


enzyme_display_name: Acyl-coenzyme A oxidase acox-1.1

organism: Caenorhabditis elegans

substrate_name: asc-C9-CoA (at 30 degrees Celsius and pH 7.4)


substrate_name: asc-C7-CoA (at 30 degrees Celsius, pH 7.4 and in complex with acox-1.3)


enzyme_display_name: Laccase

organism: Bacillus subtilis (strain 168)

substrate_name: ABTS


substrate_name: syringaldazine


organism: Escherichia coli

substrate_name: NAD+; Coenzyme A; Pyruvate


organism: Sus scrofa

substrate_name: Hexacyanoferrate(III); Pyruvate; H2O


organism: Corynebacterium glutamicum

substrate_name: 2,6-Dichloroindophenol; 2-Oxoglutarate


enzyme_display_name: dihydrolipoyl dehydrogenase

organism: Fasciola hepatica

substrate_name: Coenzyme A; NAD+; 2-Oxoglutarate


substrate_name: Thiamine diphosphate; 2-Oxoglutarate


organism: Rattus norvegicus

substrate_name: 2-Oxoglutarate; Coenzyme A; NAD+


organism: Solanum tuberosum

substrate_name: 2-Oxoglutarate; NAD+; Coenzyme A


organism: Teladorsagia circumcincta


organism: Xenopus laevis

substrate_name: Coenzyme A; 2-Oxoglutarate; NAD+


substrate_name: Acceptor; alpha-Ketovaline; H2O


source_license: CC BY 4.0; SABIO-RK terms (free for academic use; see sabiork.h-its.org); CC BY-NC-ND 4.0


enzyme_display_name: Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

organism: Mus musculus


enzyme_display_name: dihydropyrimidine dehydrogenase (NADP+)

substrate_name: H+; NADPH; Uracil


organism: Canis familiaris


organism: Macaca fuscata


organism: Oryctolagus cuniculus

substrate_name: 1,2-Dihydronaphthalene-1,2-diol; NADP+


enzyme_display_name: 2-methylene-furan-3-one reductase

organism: Fragaria ananassa


enzyme_display_name: UniProt P9WGR1

organism: Mycobacterium tuberculosis


enzyme_display_name: prephenate dehydrogenase

substrate_name: Prephenate; NAD+


enzyme_display_name: 1-cyclohexenylcarbonyl-CoA reductase

organism: Streptomyces collinus


enzyme_display_name: 8-oxogeranial reductase

organism: Antirrhinum majus

substrate_name: H+; NADPH; 8-Oxogeranial


enzyme_display_name: UniProt Q16698

organism: Homo sapiens


enzyme_display_name: 7-dehydrocholesterol reductase

substrate_name: NADPH; H+; Cholesta-5,7-dien-3beta-ol


enzyme_display_name: cholestenone 5alpha-reductase

organism: Arabidopsis thaliana

substrate_name: Progesterone; NADPH; H+


substrate_name: Testosterone; H+; NADPH


substrate_name: H+; Testosterone; NADPH


organism: Solanum lycopersicum

substrate_name: H+; Progesterone; NADPH


enzyme_display_name: 2,4-dienoyl-CoA reductase (NADPH)


enzyme_display_name: Trans-2-enoyl-CoA reductase

organism: Euglena gracilis

substrate_name: (2E)-butenoyl-CoA (crotonyl-CoA) (in the presence of NADH)


enzyme_display_name: enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)

organism: Bacillus subtilis


organism: Staphylococcus aureus


substrate_name: NADPH; But-2-enoyl-[acyl-carrier protein]; H+


enzyme_display_name: trans-2-enoyl-CoA reductase (NAD+)

substrate_name: H+; Crotonoyl-CoA; NADH


enzyme_display_name: pyruvate synthase

organism: Acetogenium kivui

substrate_name: Oxidized ferredoxin; Pyruvate; Coenzyme A


enzyme_display_name: aldehyde ferredoxin oxidoreductase

organism: Caldicellulosiruptor bescii

substrate_name: oxidized ferredoxin


organism: Pyrococcus furiosus

substrate_name: D-Glyceraldehyde 3-phosphate; H2O; Oxidized benzyl viologen


organism: Desulfovibrio gigas


enzyme_display_name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)

substrate_name: NADPH; Crotonoyl-CoA


substrate_name: NADPH; Crotonoyl-CoA; H+


enzyme_display_name: L-galactonolactone dehydrogenase

organism: Brassica oleracea

substrate_name: Cytochrome c; L-Galactono-1,4-lactone


enzyme_display_name: coproporphyrinogen oxidase

organism: Gallus gallus


enzyme_display_name: protoporphyrinogen oxidase

organism: Aquifex aeolicus

substrate_name: Protoporphyrinogen IX; O2


substrate_name: Mesoporphyrinogen-IX


substrate_name: O2; Protoporphyrinogen IX


organism: Pseudomonas aeruginosa


substrate_name: NADH; trans-Dodec-2-enoyl-[acp]; H+


organism: Streptococcus pneumoniae

substrate_name: Crotonoyl-CoA; NADH; H+


organism: Vibrio cholerae

substrate_name: NADH; But-2-enoyl-[acyl-carrier protein]; H+


enzyme_display_name: UniProt Q8Z9U1

organism: Yersinia pestis


enzyme_display_name: UDP-N-acetylmuramate dehydrogenase

organism: Escherichia coli


organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)


enzyme_display_name: 15-oxoprostaglandin 13-oxidase

organism: Homo sapiens


organism: Mus musculus


organism: Alcaligenes faecalis

substrate_name: PDD (at pH 9 and 30 degrees Celsius)


organism: Comamonas testosteroni


organism: Myxococcus xanthus


organism: Rattus norvegicus


organism: Saccharomyces cerevisiae


enzyme_display_name: bilirubin oxidase

organism: Bacillus pumilus


organism: Bacillus sp. HR03

substrate_name: Bilirubin; O2


organism: Halobacterium volcanii


organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

substrate_name: butyrlaldehyde (in the presence of HsaF)


organism: Paraburkholderia xenovorans

substrate_name: pentaldehyde


enzyme_display_name: Acetaldehyde dehydrogenase (acetylating) EutE

organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

substrate_name: Unknown


organism: Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)

substrate_name: [LysW]-aminoadipate 6-semialdehyde


enzyme_display_name: Aspartate-semialdehyde dehydrogenase

organism: Blastomyces gilchristii (strain SLH14081)


organism: Candida albicans (strain SC5314 / ATCC MYA-2876)


enzyme_display_name: UniProt Q46381


enzyme_display_name: fumarate reductase (NADH)

organism: Enterococcus faecalis

substrate_name: Fumarate; Reduced FMN


organism: Klebsiella pneumoniae

substrate_name: Fumarate; H+; NADH


enzyme_display_name: anthocyanidin reductase

organism: Medicago truncatula

substrate_name: Cyanidin; NADP+


substrate_name: Delphinidin; NADP+


organism: Vitis vinifera


enzyme_display_name: acrylyl-CoA reductase (NADPH)

organism: Sulfolobus tokodaii

substrate_name: NADPH; Acryloyl-CoA; H+


organism: Cryptococcus deneoformans (strain JEC21 / ATCC MYA-565)

substrate_name: L-aspartate 4-semialdehyde in the reverse direction (at 25 degrees Celsius and at pH 8.6)


enzyme_display_name: aspartate-semialdehyde dehydrogenase


organism: Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892)


organism: Escherichia coli

substrate_name: NAD+; Phosphate; D-Glyceraldehyde 3-phosphate


organism: Glycine max

substrate_name: Phosphate; D-Glyceraldehyde 3-phosphate; NAD+


organism: Lactococcus lactis subsp. lactis

substrate_name: D-Glyceraldehyde 3-phosphate; NAD+; Phosphate


enzyme_display_name: Trans-2-enoyl-CoA reductase

organism: Euglena gracilis

substrate_name: (2E)-butenoyl-CoA (crotonyl-CoA) (in the presence of NADH)


organism: Arabidopsis thaliana

substrate_name: Crotonoyl-CoA; NADH; H+


organism: Bacillus subtilis


enzyme_display_name: UniProt Q3JQY0

organism: Burkholderia pseudomallei


organism: Plasmodium falciparum

substrate_name: Crotonoyl-CoA; H+; NADH


substrate_name: H+; NADH; Crotonoyl-CoA


substrate_name: H+; Crotonoyl-CoA; NADH


organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)


organism: Palinurus versicolor


organism: Staphylococcus aureus (strain MRSA252)


organism: Ustilago maydis

substrate_name: Phosphate; NAD+; D-Glyceraldehyde 3-phosphate


organism: Zymomonas mobilis

substrate_name: 3-Phospho-D-glyceroyl phosphate; NADH; H+


enzyme_display_name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

organism: Spinacia oleracea

substrate_name: Glycerate 1,3-bisphosphate; H+; NADPH


organism: Blastobotrys adeninivorans

substrate_name: Unknown


organism: Candida maltosa


organism: Burkholderia cepacia


organism: Mus musculus


organism: Pseudomonas putida


enzyme_display_name: biliverdin reductase

organism: Cavia porcellus

substrate_name: biliverdin IX alpha


organism: Homo sapiens

substrate_name: biliverdin IX beta


organism: Rattus norvegicus


enzyme_display_name: Delta4-3-oxosteroid 5beta-reductase

substrate_name: H+; Testosterone; NADPH


enzyme_display_name: 2,4-dienoyl-CoA reductase (NADPH)


enzyme_display_name: 2,5-dioxovalerate dehydrogenase

organism: Azospirillum brasilense

substrate_name: H2O; NAD+; 2,5-Dioxopentanoate


substrate_name: 2,5-Dioxopentanoate; NAD+; H2O


organism: Bacillus subtilis (strain 168)

substrate_name: alpha-ketoglutaric semialdehyde (in the presence of NAD(+), at 25 degrees Celsius and pH 7.2)


organism: Antirrhinum majus


enzyme_display_name: Aldehyde dehydrogenase 1A1

organism: Bos taurus


organism: Macaca fascicularis


enzyme_display_name: Retinaldehyde dehydrogenase 3


enzyme_display_name: retinal dehydrogenase

organism: Oryctolagus cuniculus

substrate_name: NAD+; H2O; Hexanal


enzyme_display_name: phenylacetaldehyde dehydrogenase

organism: Aromatoleum aromaticum

substrate_name: Phenylacetaldehyde; H2O; NADP+


substrate_name: NAD+; H2O; Phenylacetaldehyde


enzyme_display_name: Aminoaldehyde dehydrogenase ALDH10A8, chloroplastic

organism: Arabidopsis thaliana


enzyme_display_name: Aminoaldehyde dehydrogenase ALDH10A9, peroxisomal


enzyme_display_name: Aminoaldehyde dehydrogenase BADH

organism: Spinacia oleracea


enzyme_display_name: Aminoaldehyde dehydrogenase 1a

organism: Zea mays


enzyme_display_name: Aldehyde dehydrogenase family 3 member B1


enzyme_display_name: 2-oxoaldehyde dehydrogenase (NADP+)

substrate_name: Pyruvate; NADPH; H+


enzyme_display_name: bilirubin oxidase

organism: Thermobaculum terrenum

substrate_name: Bilirubin; O2


enzyme_display_name: Acyl-coenzyme A oxidase 2, peroxisomal


enzyme_display_name: Peroxisomal acyl-coenzyme A oxidase 1


enzyme_display_name: acyl-CoA oxidase

substrate_name: O2; Palmitoyl-CoA


substrate_name: Palmitoyl-CoA; O2


substrate_name: O2; Octanoyl-CoA


enzyme_display_name: Aminoaldehyde dehydrogenase 1, peroxisomal

organism: Pisum sativum


enzyme_display_name: Aminoaldehyde dehydrogenase 2, peroxisomal


organism: Escherichia coli (strain K12)


enzyme_display_name: carboxylate reductase (NADP+)

organism: Nocardia iowensis


organism: Acanthopagrus schlegelii


enzyme_display_name: cinnamoyl-CoA reductase

organism: Fragaria x ananassa

substrate_name: caffeoyl-CoA


enzyme_display_name: Cinnamoyl-CoA reductase 1

organism: Medicago truncatula


enzyme_display_name: Cinnamoyl-CoA reductase 2


enzyme_display_name: Cinnamoyl-CoA reductase CAD2


organism: Petunia hybrida


organism: Mycobacterium smegmatis

substrate_name: H2O; Succinate semialdehyde; NADP+


organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

substrate_name: butyrlaldehyde (in the presence of HsaF)


organism: Paraburkholderia xenovorans

substrate_name: pentaldehyde


organism: Mus musculus

substrate_name: Unknown


organism: Streptomyces coelicolor


organism: Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)


enzyme_display_name: UniProt G3X982


enzyme_display_name: Aldehyde oxidase 4


enzyme_display_name: aldehyde oxidase

organism: Oryctolagus cuniculus


enzyme_display_name: (methyl)glyoxal oxidase

organism: Phanerodontia chrysosporium


enzyme_display_name: 2-Hydroxyacid oxidase 1

organism: Homo sapiens

substrate_name: 2-hydroxy octanoate (at pH 7.5 and 37 degrees Celsius, with DCIP as electron acceptor)


enzyme_display_name: L-lactate oxidase

organism: Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)


enzyme_display_name: Pyruvate:ferredoxin oxidoreductase

organism: Moorella thermoacetica (strain ATCC 39073 / JCM 9320)

substrate_name: oxidized ferredoxin


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase 2, subunit beta

organism: Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase 2, subunit alpha


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase 1, subunit alpha


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase 1, subunit beta


enzyme_display_name: 2-oxoacid oxidoreductase (ferredoxin)

organism: Halobacterium salinarum


enzyme_display_name: Indole-3-acetaldehyde oxidase

organism: Arabidopsis thaliana


organism: Zea mays


enzyme_display_name: dihydrolipoyl dehydrogenase

organism: Bos taurus

substrate_name: Pyruvate; NAD+; Coenzyme A


enzyme_display_name: Pyruvate dehydrogenase [ubiquinone]

organism: Escherichia coli (strain K12)

substrate_name: pyruvate, non-activated form


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase subunit alpha

organism: Sulfolobus sp


enzyme_display_name: 2-oxoacid:ferredoxin oxidoreductase subunit beta


organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)


enzyme_display_name: PE-PGRS family protein PE_PGRS45

organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)


enzyme_display_name: Aldehyde oxidase 4


enzyme_display_name: aldehyde oxidase


organism: Macaca fascicularis


enzyme_display_name: Aldehyde oxidase 1

organism: Mus musculus


enzyme_display_name: coproporphyrinogen III oxidase (coproporphyrin-forming)

organism: Halothece sp. PCC 7418

substrate_name: protoporphyrinogen IX


organism: Apium graveolens

substrate_name: NADP+; H2O; D-Glyceraldehyde 3-phosphate


organism: Spinacia oleracea

substrate_name: H2O; D-Glyceraldehyde 3-phosphate; NADP+


organism: Triticum aestivum

substrate_name: H2O; NADP+; D-Glyceraldehyde 3-phosphate


organism: Thermoproteus tenax


enzyme_display_name: Aldehyde dehydrogenase family 3 member A2

organism: Homo sapiens


enzyme_display_name: 3-sulfolactaldehyde dehydrogenase

organism: Pseudomonas putida


enzyme_display_name: Coproporphyrinogen III oxidase

organism: Bacillus subtilis (strain 168)

substrate_name: coproporphyrinogen III


enzyme_display_name: L-galactonolactone oxidase

organism: Trypanosoma cruzi


enzyme_display_name: albonoursin synthase

organism: Streptomyces noursei

substrate_name: cyclo(L-Leu-L-Phe)


enzyme_display_name: UniProt Q02127

substrate_name: dihydroorotate


substrate_name: coenzyme Q0


enzyme_display_name: UniProt Q63707

organism: Rattus norvegicus


enzyme_display_name: benzylmalonyl-CoA dehydrogenase

organism: Aromatoleum aromaticum

substrate_name: benzylmalonyl-CoA


enzyme_display_name: fumarate reductase (CoM/CoB)

organism: Methanothermobacter thermautotrophicus

substrate_name: fumarate


organism: Saccharomyces cerevisiae


substrate_name: oxygen


organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)


enzyme_display_name: 9,9'-dicis-zeta-carotene desaturase

organism: Rubrivivax gelatinosus

substrate_name: phytoene


enzyme_display_name: succinate dehydrogenase (ubiquinone)

organism: Ascaris suum

substrate_name: Reduced acceptor; Fumarate


enzyme_display_name: succinate dehydrogenase

substrate_name: Fumarate


substrate_name: Succinate; Ubiquinone-2


substrate_name: Acceptor; Succinate


substrate_name: FAD; Succinate


organism: Shewanella frigidimarina


substrate_name: succinate


organism: Desulfobulbus elongatus


enzyme_display_name: dihydroorotate dehydrogenase (quinone)

organism: Lactococcus lactis


organism: Enterococcus faecalis

substrate_name: S-dihydroorotate


organism: Bacillus subtilis

substrate_name: Menadione; L-Dihydroorotate


enzyme_display_name: Acetyl-CoA decarbonylase/synthase complex subunit alpha 1

organism: Methanosarcina barkeri (strain Fusaro / DSM 804)

substrate_name: Unknown


enzyme_display_name: anaerobic carbon monoxide dehydrogenase

organism: Rhodospirillum rubrum


enzyme_display_name: aldehyde ferredoxin oxidoreductase

organism: Pyrococcus furiosus

substrate_name: Formaldehyde; Methyl viologen; H2O


organism: Thermococcus litoralis


enzyme_display_name: NAD-dependent dihydropyrimidine dehydrogenase subunit PreA

organism: Escherichia coli (strain K12)


enzyme_display_name: NAD-dependent dihydropyrimidine dehydrogenase subunit PreT


organism: Ipomoea batatas


enzyme_display_name: fumarate reductase (menaquinone)

organism: Mycobacterium bovis


organism: Drosophila melanogaster

substrate_name: (S)-dihydroorotate


mutation_signature: Δ2


substrate_name: decylubiquinone


organism: Escherichia coli


organism: Candida albicans

substrate_name: dihydroorotate


mutation_signature: N-terminally truncated DHODH N-terminally truncated DHODH


mutation_signature: N-terminally truncated DHODH / 6-dichloroindophenol from 0-0.2 mM N-terminally truncated DHODH


mutation_signature: N-terminally truncated DHODH / fixed concentration of dihydroorotate of 1.0 mM and varied concentrations of decylubiquinone from 0-0.2 mM N-terminally truncated


mutation_signature: N-terminally truncated DHODH / 6-dichloroindophenol N-terminally truncated DHODH


enzyme_display_name: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

substrate_name: fumarate (adult complex II, at 25 degrees Celsius and in anaerobic conditions)


enzyme_display_name: Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial


substrate_name: fumarate


substrate_name: succinate (at 37 degrees Celsius)


enzyme_display_name: Protoporphyrinogen IX dehydrogenase [quinone]

substrate_name: protoporphyrinogen IX


substrate_name: menadione (a soluble menaquinone analog)


enzyme_display_name: coproporphyrinogen III oxidase (coproporphyrin-forming)

organism: Phormidium nigroviride


substrate_name: menaquinone


organism: Mycobacterium smegmatis

substrate_name: Reduced acceptor; Fumarate


organism: Ascaris suum

substrate_name: succinate (free larvae complex II, at 25 degrees Celsius)


organism: Mammalia


substrate_name: phenazine methosulfate


organism: Bos taurus

substrate_name: Ubiquinone; L-Dihydroorotate


organism: Homo sapiens

substrate_name: L-Dihydroorotate; Ubiquinone


enzyme_display_name: Dihydroorotate dehydrogenase (quinone), mitochondrial

organism: Plasmodium falciparum (isolate 3D7)


organism: Rattus norvegicus

source_license: SABIO-RK terms (free for academic use; see sabiork.h-its.org); CC BY-NC-ND 4.0


organism: Saccharomyces kluyveri

substrate_name: L-Dihydroorotate; Decylubiquinone


organism: Schizosaccharomyces pombe

substrate_name: Decylubiquinone; L-Dihydroorotate


organism: Helicobacter pylori

substrate_name: Fumarate; Reduced acceptor


organism: Capsicum annuum

substrate_name: Neurosporene; Decylplastoquinone


enzyme_display_name: 6-hydroxynicotinate reductase

organism: Eubacterium barkeri

substrate_name: reduced ferrodoxin


organism: Escherichia coli (strain K12)


enzyme_display_name: 15-cis-phytoene desaturase

organism: Narcissus pseudonarcissus


enzyme_display_name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial

substrate_name: ubquinone-1 (free larvae complex II, succinate as cosubstrate and at 25 degrees Celsius)


enzyme_display_name: succinate dehydrogenase (ubiquinone)

organism: Escherichia coli

substrate_name: Menaquinone; Succinate


substrate_name: Ubiquinone; Succinate


organism: Shewanella frigidimarina


substrate_name: FADH2; Fumarate


organism: Bacillus subtilis


enzyme_display_name: 2-methylene-furan-3-one reductase

organism: Solanum lycopersicum


enzyme_display_name: prephenate dehydrogenase

organism: Aquifex aeolicus

substrate_name: Unknown


substrate_name: prephenate


substrate_name: NAD+


enzyme_display_name: Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit

organism: Bacillus subtilis (strain 168)


substrate_name: NADP+; Acenaphthen-1-ol


enzyme_display_name: 3-oxo-5-alpha-steroid 4-dehydrogenase 2


enzyme_display_name: enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

organism: Staphylococcus aureus

substrate_name: dodecenoyl-[Staphylococcus aureus acyl carrier protein]


substrate_name: crotonyl-[acyl-carrier protein]


enzyme_display_name: 2-alkenal reductase (NADP(+)-dependent)

organism: Nicotiana tabacum

substrate_name: methyl-trans-2-methylcinnamaldehyde (at pH 7.3)


organism: Fragaria ananassa


enzyme_display_name: 3-oxo-5-alpha-steroid 4-dehydrogenase 1

organism: Homo sapiens


enzyme_display_name: biliverdin reductase

substrate_name: NADP+


substrate_name: biliverdin


substrate_name: methyl 2,3-dihydro-2,3-dihydroxybenzoate (at pH 7.4 and 37 degrees Celsius)


organism: Pseudomonas putida


organism: Yersinia pestis


enzyme_display_name: arogenate dehydrogenase (NADP+)

organism: Arabidopsis thaliana


enzyme_display_name: acrylyl-CoA reductase (NADPH)

organism: Cereibacter sphaeroides

substrate_name: NADH


organism: Ruegeria pomeroyi


enzyme_display_name: Crotonyl-CoA carboxylase/reductase

organism: Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)

substrate_name: (2E)-butenoyl-CoA (in the reductive carboxylation assay)


organism: Haemophilus influenzae

substrate_name: NADH; H+; But-2-enoyl-[acyl-carrier protein]


enzyme_display_name: Fatty acid synthase


organism: Rattus norvegicus


enzyme_display_name: 12-oxophytodienoate reductase 3


enzyme_display_name: Prostaglandin reductase 1

organism: Cavia porcellus


enzyme_display_name: Prostaglandin reductase-3

organism: Mus musculus


organism: Sus scrofa


organism: Digitalis lanata


enzyme_display_name: Delta4-3-oxosteroid 5beta-reductase


enzyme_display_name: protochlorophyllide reductase

organism: Thermosynechococcus elongatus

substrate_name: Protochlorophyllide; H+; NADPH


enzyme_display_name: trans-2-enoyl-CoA reductase (NADPH)

organism: Bos taurus

substrate_name: H+; NADPH; trans-Dec-2-enoyl-CoA


substrate_name: H+; trans-Hex-2-enoyl-CoA; NADPH


enzyme_display_name: albonoursin synthase

organism: Streptomyces noursei

substrate_name: cyclo(L-Phe-L-His)


enzyme_display_name: Aclacinomycin-N/aclacinomycin-A oxidase

organism: Streptomyces galilaeus

substrate_name: AclA


enzyme_display_name: Coproporphyrinogen III oxidase

organism: Bacillus subtilis (strain 168)

substrate_name: mesoporphyrinogen IX


enzyme_display_name: Benzylmalonyl-CoA dehydrogenase

organism: Aromatoleum aromaticum (strain DSM 19018 / LMG 30748 / EbN1)

substrate_name: Unknown


organism: Escherichia coli (strain K12)


enzyme_display_name: coproporphyrinogen oxidase

organism: Homo sapiens

substrate_name: Coproporphyrinogen-III


organism: Mycobacterium tuberculosis

substrate_name: 2-trans-Dodecenoyl-CoA; H+; NADH


organism: Mycolicibacterium smegmatis


organism: Spinacia oleracea

substrate_name: H+; NADH; But-2-enoyl-[acyl-carrier protein]


organism: Staphylococcus aureus

substrate_name: H+; NADH; Crotonoyl-CoA


organism: Streptococcus pneumoniae


substrate_name: mesoporphyrinogen-VI


enzyme_display_name: protoporphyrinogen oxidase

organism: Bacillus subtilis


organism: Yersinia pestis


enzyme_display_name: acrylyl-CoA reductase (NADH)

organism: Clostridium propionicum

substrate_name: H+; Acryloyl-CoA; NADH


enzyme_display_name: Botryococcus squalene synthase

organism: Botryococcus braunii


enzyme_display_name: NADPH-dependent curcumin reductase


enzyme_display_name: L-galactonolactone dehydrogenase

organism: Arabidopsis thaliana

substrate_name: cytochrome c


enzyme_display_name: Succinate dehydrogenase [rhodoquinone] flavoprotein subunit 1, mitochondrial

organism: Ascaris suum

substrate_name: ubquinone-1 (adult complex II, succinate as cosubstrate and at 25 degrees Celsius)


enzyme_display_name: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

substrate_name: ubquinone-1 (adult and larval complex II, succinate as cosubstrate and at 25 degrees Celsius)


organism: Bos taurus


enzyme_display_name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial


enzyme_display_name: succinate dehydrogenase

organism: Escherichia coli


substrate_name: ubiquinone


enzyme_display_name: protoporphyrinogen IX dehydrogenase (menaquinone)

substrate_name: Menadione; Protoporphyrinogen IX


enzyme_display_name: fumarate reductase (menaquinone)

substrate_name: Reduced acceptor; Fumarate


organism: Oryza sativa subsp. indica


substrate_name: reduced plumbagin


enzyme_display_name: dihydroorotate dehydrogenase (quinone)

organism: Candida albicans

substrate_name: Decylubiquinone; L-Dihydroorotate


organism: Enterococcus faecalis

substrate_name: Menadione; L-Dihydroorotate


substrate_name: protoporphyrinogen-IX


enzyme_display_name: bilirubin oxidase

organism: Albifimbria verrucaria


enzyme_display_name: Laccase

organism: Bacillus subtilis (strain 168)

substrate_name: SGZ


enzyme_display_name: Acyl-coenzyme A oxidase acox-1.1

organism: Caenorhabditis elegans

substrate_name: asc-omega-C5-CoA (at 30 degrees Celsius, pH 7.4 and in complex with acox-1.2)


enzyme_display_name: Peroxisomal acyl-coenzyme A oxidase 1

organism: Phascolarctos cinereus

substrate_name: Unknown


enzyme_display_name: 2-alkenal reductase

substrate_name: 4-Hydroxycinnamyl aldehyde; NADPH; H+


enzyme_display_name: Prostaglandin reductase 1

organism: Cavia porcellus


organism: Sus scrofa


enzyme_display_name: anthocyanidin reductase

substrate_name: NADP+; Cyanidin


enzyme_display_name: arogenate dehydrogenase (NADP+)

substrate_name: L-Arogenate; NADP+


substrate_name: fumarate


substrate_name: Fumarate


substrate_name: succinate


substrate_name: L-malate


substrate_name: D-malate


enzyme_display_name: 2-methylene-furan-3-one reductase

organism: Fragaria x ananassa


enzyme_display_name: L-galactonolactone dehydrogenase


substrate_name: Ferricytochrome c


substrate_name: Phenazine methosulfate


enzyme_display_name: acyl-CoA oxidase

organism: Rattus norvegicus

substrate_name: octanoyl-CoA


organism: Streptomyces collinus

substrate_name: NADPH


enzyme_display_name: 1-cyclohexenylcarbonyl-CoA reductase


enzyme_display_name: protoporphyrinogen oxidase

organism: Myxococcus xanthus

substrate_name: protoporphyrinogen IX


enzyme_display_name: succinate dehydrogenase

organism: Shewanella frigidimarina


enzyme_display_name: tetrahydroberberine oxidase

organism: Berberis wilsoniae

substrate_name: (S)-Tetrahydrojatrorrhizine


substrate_name: (S)-canadine


enzyme_display_name: Tetrahydroberberine oxidase

substrate_name: (S)-scoulerine


substrate_name: (S)-tetrahydropalmatine


enzyme_display_name: dihydroorotate dehydrogenase (quinone)

organism: Bos taurus

substrate_name: L-Dihydroorotate


substrate_name: menadione


substrate_name: ubiquinone


enzyme_display_name: Dihydroorotate dehydrogenase (quinone), mitochondrial

substrate_name: (S)-dihydroorotate


substrate_name: decylplastoquinone (DPQ)


substrate_name: phytoene


substrate_name: phytofluene


enzyme_display_name: Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

organism: Mus musculus


substrate_name: Decylubiquinone


substrate_name: Fumarate


substrate_name: succinate


enzyme_display_name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial

organism: Ascaris suum

substrate_name: succinate (free larvae complex II, at 25 degrees Celsius)


substrate_name: fumarate (free larvae complex II, at 25 degrees Celsius)


organism: Arabidopsis thaliana

substrate_name: dihydroorotate


substrate_name: decylubiquinone


enzyme_display_name: Fumarate reductase (CoM/CoB) subunit B

organism: Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)

substrate_name: fumarate


enzyme_display_name: Fumarate reductase (CoM/CoB) subunit A


organism: Saccharomyces kluyveri


enzyme_display_name: protoporphyrinogen IX dehydrogenase (quinone)

organism: Escherichia coli

substrate_name: Protoporphyrinogen IX


enzyme_display_name: (S)-8-oxocitronellyl enol synthase

organism: Catharanthus roseus


organism: Capsicum annuum

substrate_name: zeta-carotene


substrate_name: neurosporene


organism: Candida albicans (strain SC5314 / ATCC MYA-2876)


enzyme_display_name: NADPH-dependent curcumin reductase

organism: Escherichia coli (strain K12)

substrate_name: curcumin


enzyme_display_name: UniProt Q16698

organism: Homo sapiens

substrate_name: NADPH


organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

substrate_name: coproporphyrinogen


organism: Schizosaccharomyces pombe


substrate_name: L-Dihydroorotate


enzyme_display_name: coproporphyrinogen oxidase

organism: Gallus gallus

substrate_name: Coproporphyrinogen-III


enzyme_display_name: L-galactonolactone dehydrogenase

organism: Brassica oleracea var. botrytis

substrate_name: L-galactono-gamma-lactone


organism: Bacillus subtilis


enzyme_display_name: Protoporphyrinogen oxidase

substrate_name: protoporphyrinogen IX


organism: Schistosoma mansoni

substrate_name: coenzyme Q0


organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843)

substrate_name: (S)-dihydroorotate


enzyme_display_name: Peroxisomal acyl-coenzyme A oxidase 1

substrate_name: hexadecanoyl-CoA (palmitoyl-CoA)


enzyme_display_name: bilirubin oxidase

organism: Halobacterium volcanii

substrate_name: bilirubin


organism: Albifimbria verrucaria

substrate_name: Biliverdin


organism: Bacillus pumilus


organism: Phascolarctos cinereus


enzyme_display_name: Acyl-coenzyme A oxidase 4, peroxisomal

organism: Arabidopsis thaliana

substrate_name: hexanoyl-CoA


enzyme_display_name: succinate dehydrogenase

organism: Escherichia coli

substrate_name: succinate


enzyme_display_name: 15-cis-phytoene desaturase

organism: Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805)

substrate_name: NADP


enzyme_display_name: UniProt Q9NUI1


enzyme_display_name: dihydroorotate dehydrogenase (quinone)

organism: Phytophthora infestans


organism: Plasmodium falciparum


substrate_name: coenzyme QD


substrate_name: coenzyme Q1


enzyme_display_name: Dihydroorotate dehydrogenase (quinone)

organism: Escherichia coli (strain K12)

substrate_name: dihydroorotate


organism: Shewanella frigidimarina

substrate_name: Fumarate


organism: Solanum tuberosum


substrate_name: ubiquinone


substrate_name: menaquinol


substrate_name: ferricyanide


organism: Synechococcus sp.

substrate_name: Phytoene


substrate_name: Coproporphyrinogen-III


enzyme_display_name: sanguinarine reductase

organism: Eschscholzia californica

substrate_name: sanguinarine