Designing the new
We design novel proteins using structure-aware AI/optimization models. Our designed proteins find application in energy, environment, therapeutics, and critical ionic separations.
We are located within the Nanovaccine Institute and affiliated to the Chemical & Biological Engineering department at Iowa State.
▲ Engineering rationale for protein pores
Protein pores act as nature's sieves, sorting molecules and ions. We can tailor these pores for targeted separations.
Cell Systems
▲ AI-guided protein structure prediction
RGN2 protein language model folds orphan and designed proteins, surpassing AlphaFold2 in efficiency.
Nature Biotech Nature News
▲ Epitope landscape of PRRSV for infecting pigs
We biophysically characterize PRRSV entry modalities in pigs in addition to CD163 cell surface receptor. Putative epitope library enables design of novel immunogenic peptides for therapeutic intervention.
Comp Str Bio J
